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Data from: Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors
负责人:
关键词:
tissue targeting;cell membrane;entropy loss upon binding;functionalized nanocarriers;pharmacodynamic model;free energy landscape
DOI:
doi:10.5061/dryad.4h76d
摘要:
a computational model to delineate the roles played by target protein expression and mechanical factors of the target cell membrane in determining the avidity
Data from: Markov-modulated continuous-time Markov chains to identify site- and branch-specific evolutionary variation in BEAST
负责人:
关键词:
Markov-modulated models;heterotachy;BEAGLE;phylogenetics;Bayesian inference;covarion;BEAST
DOI:
doi:10.5061/dryad.230s5h0
摘要:
on, we show that MMMs impact phylogenetic tree estimation and can substantially improve model fit compared to standard substitution models. Throug
Data from: Computer simulations show that Neanderthal facial morphology represents adaptation to cold and high energy demands, but not heavy biting
负责人:
关键词:
Homo heidelbergensis;Recent;Computational fluid dynamics;Homo neanderthalensis;finite element analysis;Homo Sapiens;Pleistocene
DOI:
doi:10.5061/dryad.39272
摘要:
ysis (FEA) and computational fluid dynamics (CFD). This is the most comprehensive application of either approach applied to date and the first to include both. FEA reveals few differences bet
Data from: Swapping birth and death: symmetries and transformations in phylodynamic models
负责人:
关键词:
Basel;maximum likelihood;phylogenetics;Bayesian inference;Phylodynamics;birth-death models;algebraic symmetries;speciation-extinction models
DOI:
doi:10.5061/dryad.57704ft
摘要:
ke a negative value. In the last part of this paper, we describe the relevance of these transformations and their application to computational phylodynamics, parti
Data from: Modeling site heterogeneity with posterior mean site frequency profiles accelerates accurate phylogenomic estimation
负责人:
关键词:
long-branch repulsion;long-branch repel;site heterogeneity;long-branch attraction;maximum likelihood;mixture model;posterior mean site frequency
DOI:
doi:10.5061/dryad.gv1q5
摘要:
-searching in place of the full mixture model. Compared with widely used empirical mixture models with k classes, our implementation of PMSF in IQ-TREE (http
Data from: Ensembler: enabling high-throughput molecular simulations at the superfamily scale
负责人:
关键词:
comparative modeling;molecular dynamics simulation;distributed simulation
DOI:
doi:10.5061/dryad.7fg32
摘要:
ious stages of modeling and refinement to produce simulation-ready structures. This includes comparative modeling to all relevant PDB structures (which may span
Data from: A branch-heterogeneous model of protein evolution for efficient inference of ancestral sequences
负责人:
关键词:
phylogeny;Optimal Growth Temperature;Non-homogeneous model;phylogenomics;Ancestral Sequence Reconstruction
DOI:
doi:10.5061/dryad.7h66k
摘要:
computational costs and potential overparameterization. Here, we present a new branch-nonhomogeneous and nonstationary model of protein evolution that captures mo
Data from: Describing complex structure-function relationships in biomolecules at equilibrium
负责人:
关键词:
statistical thermodynamics;fluorescence landscapes;Periplasmic binding proteins;Glucose biosensor;Nested equilibrated states trees;nest;Protein structure-function relationships
DOI:
doi:10.5061/dryad.rr4xgxd5b
摘要:
computational method to handle arbitrarily complex systems.? To demonstrate this approach, we collected a multi-dimensional fluorescence landscape of an engineered
Data from: A morphometric analysis of vegetation patterns in dryland ecosystems
负责人:
Mander, Luke
关键词:
vegetation patterns morphology morphometrics ecohydrology computational vision
DOI:
doi:10.5061/dryad.5d19r
摘要:
of patterned vegetation produced by a computational model and a small set of satellite images from South Kordofan (South Sudan), which illustrates tha

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