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Data from: Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice
负责人:
关键词:
Serotonin Optogenetics
DOI:
doi:10.5061/dryad.nh437
摘要:
to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons
Data from: Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle
负责人:
关键词:
fMRI;pharmacological fMRI;pharmacodynamics;phMRI;drug development;EC50;pharmacokinetic-pharmacodynamic modeling;ED50;neuroimaging;dose-finding
DOI:
doi:10.5061/dryad.s3443
摘要:
fMRI studies of primate brain using a dopamine agonist, the observed noise level is modest compared with observed drug effects, and a quantitative EC50
Data from: Sources of variability in cytosolic calcium transients triggered by stimulation of homogeneous uro-epithelial cell monolayers
负责人:
关键词:
Heterogeneity;wound repair;regeneration;automated image analysis;segmentation;epithelium;calcium signalling;urothelium
DOI:
doi:10.5061/dryad.mn8cs
摘要:
of cultured non-immortalized normal human urothelial cells when subjected to either the global application of an external agonist or a localized scratch wound
Data from: Longitudinal analysis of impulse control disorders in Parkinson’s disease
负责人:
关键词:
Cohort studies;All Neuropsychology\/Behavior;Natural history studies (prognosis);All Psychiatric disorders;Parkinson's disease\/Parkinsonism
DOI:
doi:10.5061/dryad.qv4kq75
摘要:
Poisson models with robust variance were used to study the association between several time-dependent definitions of dopamine agonist (DA) use, taking dose
Data from: Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis
负责人:
关键词:
apoM;Mus musculus;blood-brain barrier;transcytosis;C57bl\/6 ApoM-\/-
DOI:
doi:10.5061/dryad.qg04542
摘要:
s transcytosis in capillaries and venules remained unchanged. S1PR1 agonist SEW2871 rapidly normalized BBB permeability along both the paracellular
Data from: Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
负责人:
关键词:
hormone secretion;GLP-1;Rattus norvegicus;Epac2;Homo Sapiens;fusion pore;Mus musculus;exocytosis;exendin-4
DOI:
doi:10.5061/dryad.6b604g8
摘要:
. Consistently, overexpression of Epac2 impedes pore expansion. Widely used antidiabetic drugs (GLP-1 receptor agonists and sulfonylureas) activate this pathway
Data from: Anxiety-like behaviour increases safety from fish predation in an amphipod crustacea
负责人:
关键词:
neuromodulation;anxiety;Gammarus fossarum;defensive-behaviour;predation;Holocene;glutamate
DOI:
doi:10.5061/dryad.3kj5s
摘要:
by pre-treatment with LY354740, a metabotropic glutamate receptor group II/III agonist. Importantly, we found that this modulation of decision making under

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