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Data from: The role of platelets in mediating a response to human influenza infection
- 负责人：
- DOI：
- doi:10.5061/dryad.786b9q0
- 摘要：
- Influenza infection increases the incidence of myocardial infarction but the reason is unknown. Platelets mediate vascular occlusion through thrombotic functions but are also recognized to have immunomodulatory activity. To determine if platelet processes are activated during influenza infection, we collected blood from 18 patients with acute influenza infection. Microscopy reveals activated platelets, many containing viral particles and extracellular- DNA associated with platelets. To understand the mechanism, we isolated human platelets and treated them with influenza A virus. Viral-engulfment leads to C3 release from platelets as a function of TLR7 and C3 leads to neutrophil-DNA release and aggregation. TLR7 specificity is confirmed in murine models lacking the receptor, and platelet depletion models support platelet-mediated C3 and neutrophil-DNA release post-influenza infection. These findings demonstrate that the initial intrinsic defense against influenza is mediated by platelet-neutrophil cross-communication that tightly regulates host immune and complement responses but can also lead to thrombotic vascular occlusion.
Data from: Specific alleles at immune genes, rather than genome-wide heterozygosity, are related to immunity and survival in the critically endangered Attwater's prairie-chicken
- 负责人：
- DOI：
- doi:10.5061/dryad.dm437
- 摘要：
- was related to alleles of the innate (Toll-like receptors, TLRs) and adaptive (major histocompatibility complex, MHC) immune systems, but not to genome-wide
Data from: Costs of immunity and their role in the range expansion of the house sparrow in Kenya
- 负责人：
- DOI：
- doi:10.5061/dryad.fn0f4
- 摘要：
- of Toll-like receptors (TLRs), leukocyte receptors that instigate inflammatory responses when bound to microbial elements, was related to the range expansion across the country
Data from: The coral immune response facilitates protection against microbes during tissue regeneration
- 负责人：
- DOI：
- doi:10.5061/dryad.r24b1
- 摘要：
- by increasing the expression of immune system-related genes involved in the Toll-like and NOD-like receptor signalling pathways and the lectin–complement system
Data from: Macroparasites at peripheral sites of infection are major and dynamic modifiers of systemic anti-microbial pattern recognition responses
- 负责人：
- DOI：
- doi:10.5061/dryad.s7t1g
- 摘要：
- anti-microbial pattern recognition receptors (PRRs) such as toll-like receptors (TLRs). Whilst PRR-mediated response programmes are the result of lon
Data from: Differential gene expression analysis of symbiotic and aposymbiotic Exaiptasia anemones under immune challenge with Vibrio coralliilyticus
- 负责人：
- DOI：
- doi:10.5061/dryad.364j18m
- 摘要：
- complement, coagulation, nucleotide-binding and oligomerization domain (NOD), and Toll for Vibrio exposure and coagulation and apoptosis for aposymbiosis.
Data from: Microevolutionary selection dynamics acting on immune genes of the green veined white butterfly, Pieris napi
- 负责人：
- DOI：
- doi:10.5061/dryad.51bp263
- 摘要：
- of the immune response as well as the Toll pathway appear to be enriched among our outlier loci, regardless of functional category. This suggests that the targets
Data from: Down-regulation of CXCL12/CXCR4 expression alleviates ischemia-reperfusion-induced inflammatory pain via inhibiting glial TLR4 activation in the spinal cord
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.5934k
- 摘要：
- Toll-like receptor 4 (TLR4) is important for the pathogenesis of inflammatory reactions and the promotion of pain processing after ischemia
Data from: Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.6hf1pc1
- 摘要：
- with specific inhibitors, analysis of the products in a Toll-like receptor reporter cell line assay, and insulin removal from the products by immunopurification
Data from: Genetic depletion at adaptive but not neutral loci in an endangered bird species
- 负责人：
- DOI：
- doi:10.5061/dryad.8c9s1
- 摘要：
- microsatellite loci and adaptive SNP variation in five Toll-like receptor (TLR) immune system genes. Bottleneck tests confirm genetic drift as the main force shaping
