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PONE-D-17-09792
- 负责人：
- 关键词：
- Neuroscience
- DOI：
- doi:10.6084/m9.figshare.5860914
- 摘要：
- enotypes reminiscent of schizophrenia, including hypersensitivity to ketamine. As accumulating evidence on molecular mechanisms and behavioral phenotypes established
Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
- 负责人：
- Zaremba, Jeff
- 关键词：
- schizophrenia hippocampus calcium imaging in vivo imaging two-photon imaging 22q11.2 deletion syndrome place cells place cell stability spatial learning reward learning
- DOI：
- doi:10.5061/dryad.rq560
- 摘要：
- mal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-oriented learning in wild-type mice
Data from: A genetic locus for paranoia
- 负责人：
- DOI：
- doi:10.5061/dryad.7g5s4
- 摘要：
- . We phenotyped a large population of typical individuals for schizophrenia-spectrum and autism-spectrum traits, and genotyped them
and schizophrenia
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.88q04
- 摘要：
- : (1) middle-aged versus elderly subjects; and (2) patients with schizophrenia versus controls. Each included two measures derived from diffusion weighted images
Data from: Common gray and white matter abnormalities in schizophrenia and bipolar disorder
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.j6q573n9h
- 摘要：
- This study aimed to investigate abnormalities in the gray matter and white matter (GM and WM, respectively) that are shared between schizophrenia (SZ
Data from: TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroenceph
- 负责人：
- Kurimoto, Emi
- 关键词：
- Monkeys Cognitive impairment Alzheimer's disease Electroencephalography Biomarkers Animal cognition Cholinergics Oral administration
- DOI：
- doi:10.5061/dryad.qp313np
- 摘要：
- ’s disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M1-selective positive allosteric modulator that improves cognitive deficits induced
Data from: Altered fronto-temporal functional connectivity in individuals at ultra-high-risk of developing psychosis
- 负责人：
- DOI：
- doi:10.5061/dryad.33f97
- 摘要：
- : These findings corroborate the fronto-temporal connectivity disruption hypothesis in schizophrenia by providing evidence supporting the altered fronto
Storie di vita, di guerra, d\u2019amicizia: uomini e animali nel 1917 (e dintorni)
- 负责人：
- 关键词：
- DOI：
- doi:10.1285/i22808949a6n2p583
- 摘要：
- did not constitute an historical breakdown for the animal condition, but brought to light the ambivalent and often even "schizophrenic" orientation tha
Data from: Cyfip1 regulates presynaptic activity during development
- 负责人：
- DOI：
- doi:10.5061/dryad.nt60p
- 摘要：
- and schizophrenia. Here we show that juvenile mice hemizygous for Cyfip1 have altered presynaptic function, enhanced protein translation, and increased levels
Data from: Disentangling selection on genetically correlated polygenic traits using whole-genome genealogies
- 负责人：
- 关键词：
- DOI：
- doi:10.6078/D11M62
- 摘要：
- genetic correlation (|rg|? = 80%; c.f. schizophrenia and bipolar disorder) while retaining high power to attribute selection to the causal trait. We apply the method to study 56
