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Development of targeted therapies for peroxisome biogenesis disorders
- 负责人：
- 关键词：
- Molecular Biology peroxisome biogenesis disorders peroxins PEX1 high-content screening small molecules induced pluripotent stem cells HepG2 cells Pex1-p.G844D mouse
- DOI：
- doi:10.25549/usctheses-c40-298640
- 摘要：
- ,000 births in America. Although the genetic basis of PBDs is well understood, there is currently no curative therapy or long-term effective treatment
Data from: Phage combination therapies for bacterial wilt disease in tomato
- 负责人：
- DOI：
- doi:10.5061/dryad.02v6wwpzq
- 摘要：
- h ecological and evolutionary processes. We studied the biocontrol efficacy of different phage combinations on Ralstonia solanacearum infecti
Data from: Signatures of polygenic adaptation associated with climate across the range of a threatened fish species with high genetic connectivity
- 负责人：
- Harrisson, Katherine
- 关键词：
- Adaptation Conservation Genetics Ecological Genetics Fisheries Management Landscape Genetics Wildlife Management
- DOI：
- doi:10.5061/dryad.57m0f
- 摘要：
- ng a combination of different approaches, including polygenic methods, when testing for signatures of adaptation in landscape genomics studies.
Data from: Long-term benefit of hepatitis C therapy in a safety net hospital system: a cross-sectional study with median 5-year follow-up
- 负责人：
- DOI：
- doi:10.5061/dryad.qc57j
- 摘要：
- ents discontinuing therapy early – 32 due to adverse events and 11 due to non-compliance. Complications on treatment were frequent, including 3 deaths. SVR
Data from: Not all surveillance data are created equal – a multi?method dynamic occupancy approach to determine rabies elimination from wildlife
- 负责人：
- DOI：
- doi:10.5061/dryad.v23517k
- 摘要：
- nge acting reports, road?kill, surveillance?trapped animals, nuisance animals, and public health samples) used by the USDA National Rabies Management Progra
Data from: Resource limitation prevents the emergence of drug resistance by intensifying within-host competition
- 负责人：
- DOI：
- doi:10.5061/dryad.v2q3v
- 摘要：
- resistant mutants arose de novo or were experimentally added before drug treatment. Our work provides proof of principle that chemotherapy paired with an “ecological
Data from: Exposure to phages has little impact on the evolution of bacterial antibiotic resistance on drug concentration gradients
- 负责人：
- DOI：
- doi:10.5061/dryad.f9h64
- 摘要：
- The use of phages for treating bacterial pathogens has recently been advocated as an alternative to antibiotic therapy. Here we test a hypothesis tha
Data from: Species composition and community structure of small pest rodents (Muridae) in cultivated and fallow fields in maize growing area
- 负责人：
- Mayamba, Alex
- DOI：
- doi:10.5061/dryad.qv9471s
- 摘要：
- ant interaction effect over the months, years and fields of trapping with significantly (p = 0.001) higher abundances during months of wet seasons and in the fir
Data from: Bee pollinator functional responses and functional effects in restored tropical forests
- 负责人：
- DOI：
- doi:10.5061/dryad.mpg4f4qv3
- 摘要：
- , geographic origin and pollination mode); comparing their frequency, diversity and interaction network structure among habitats; and searching for key interacti
Data from: First circumglobal assessment of Southern Hemisphere humpback whale mitochondrial genetic variation and implications for management
- 负责人：
- DOI：
- doi:10.5061/dryad.8cs4f
- 摘要：
- o support effective management efforts. Assessments for globally distributed species are rare, however, requiring significant international coordination
