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Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
- 负责人：
- DOI：
- doi:10.5061/dryad.mb463
- 摘要：
- in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway
Data from: Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
- 负责人：
- DOI：
- doi:10.5061/dryad.vh36n
- 摘要：
- s introduced into clinical practice on the basis of target-based drug discovery. Fifty years later, PAS continues to be used to treat tuberculosis. PAS
The E3-ubiquitin ligase adaptor protein Skp1 is glycosylated by an evolutionarily conserved pathway that regulates protist growth and development.pdf
- 负责人：
- 关键词：
- 60102 Bioinformatics Cell Biology Microbiology Parasitology 60307 Host-Parasite Interactions 60502 Infectious Agents 110309 Infectious Diseases Pathology 60411 Population, Ecological and Evolutionary Genetics 60109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
- DOI：
- doi:10.6084/m9.figshare.5505661.v1
- 摘要：
- of this enzyme. In an unrelated protist, Dictyostelium discoideum, Skp1 hydroxyproline is modified by 5 sugars via the action of three glycosyltransferases, Gnt1
Data from: Strain identification and quorum sensing inhibition characterization of marine-derived Rhizobium sp. NAO1
- 负责人：
- 关键词：
- Bacterium;Biofilm;open ocean;Mesozoic;Quorum-sensing inhibition;Rhizobium sp. NAO1;virulence factors
- DOI：
- doi:10.5061/dryad.27630
- 摘要：
- d Rhizobium sp. NAO1 has the potential to serve as a QS inhibitor and may be a new microbial resource for drug development.
Data from: Formin is associated with left-right asymmetry in the pond snail and the frog
- 负责人：
- DOI：
- doi:10.5061/dryad.r4342
- 摘要：
- on existing models, we discovered asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry. As the formin-actin filament ha
Data from: Hypogonadism and low bone mineral density in patients on long-term intrathecal opioid delivery therapy
- 负责人：
- DOI：
- doi:10.5061/dryad.vj7k2
- 摘要：
- e at or above the intervention threshold for hip fracture. Conclusions: This study suggests an association between hypogonadism and low bone mass density
Data from: Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders by inducing a gene expression switch toward fatty acid oxidation in SHR.Cg
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.3hj96
- 摘要：
- of metabolic networks has become a focus of current drug discovery research into the prevention and treatment of metabolic disorders associated with energy surplus
Data from: Predicting function from sequence in a large multifunctional toxin family
- 负责人：
- DOI：
- doi:10.5061/dryad.16pg7
- 摘要：
- arch and treatment tools for human disease. Experimental characterisation of individual toxin activities is a severe rate-limiting step in the discovery process
Antimalarial activity, toxicity, pharmacokinetics and metabolic drug interaction of Plumbago Indica linn.
- 负责人：
- Kesara Na-Bangchang, Advisor
- 关键词：
- Plumbagin Antimalarial Plasmodium falciparum Plasmodium berghei Permeability Transport Efflux transporters Caco-2 cell P-glycoprotein Pharmacokinetics
- DOI：
- doi:10.14457/tu.the.2015.159
- 摘要：
- treatment of the disease, there is a pressing need for ongoing drug discovery research. Natural products including medicinal plants may offer relative
Data from: Whole genome-sequencing and phylogenetic analysis of a historical collection of Bacillus anthracis strains from Danish cattle
- 负责人：
- DOI：
- doi:10.5061/dryad.0h82m
- 摘要：
- for outbreaks of injection anthrax in drug users in Europe. Eight novel diagnostic SNPs that specifically discriminate the different sub-groups of Danish strains
