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Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
- 负责人：
- Zaremba, Jeff
- 关键词：
- hippocampus calcium imaging in vivo imaging two-photon imaging schizophrenia 22q11.2 deletion syndrome place cells place cell stability spatial learning reward learning
- DOI：
- doi:10.5061/dryad.rq560
- 摘要：
- dynamics in health and disease remains elusive. Using chronic two-photon Ca2+ imaging in hippocampal area CA1 of wild-type and Df(16)A+/? mice, an animal model
Data from: Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus
- 负责人：
- Scott, Rodney
- DOI：
- doi:10.5061/dryad.494j5
- 摘要：
- to place cell fidelity used as a surrogate of spatial cognition. We find that MAM disrupts FST and place-modulated rate coding in hippocampal CA1 and that EE
Data from: Multi-contrast submillimetric 3-Tesla hippocampal subfield segmentation protocol and dataset
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.gc72v
- 摘要：
- the hippocampal formation into three subregions: subicular complex, merged Cornu Ammonis 1, 2 and 3 (CA1-3) subfields, and CA4-dentate gyrus (CA4-DG). Segmentation was guided
Data from: Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples
- 负责人：
- 关键词：
- sharp-wave ripples
- DOI：
- doi:10.5061/dryad.qnk98sfbb
- 摘要：
- in relation to CA1 multiunit activity (MUA) and SWR, we find that the largest SWR-related modulation occurs in retrosplenial cortex; however, contrary
Data from: Structured inhibitory activity dynamics in new virtual environments
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.f83kt85
- 摘要：
- exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- and parvalbumin-expressing interneurons
Data from: Chemogenetic interrogation of a brain-wide fear memory network in mice
- 负责人：
- 关键词：
- CA1 Graph theory hippocampus neocortex contextual fear conditioning chemogenetics functional connectivity network reuniens thalamic nucleus lateral septal nucleus
- DOI：
- doi:10.5061/dryad.86337
- 摘要：
- Behavior depends on coordinated activity across multiple brain regions. Within such networks, highly connected hub regions are assumed to disproportionately influence behavioral output, although this hypothesis has not been systematically evaluated. Previously, by mapping brain-wide expression of the activity-regulated gene c-fos, we identified a network of brain regions co-activated by fear memory. To test the hypothesis that hub regions are more important for network function, here, we simulated node deletion in silico in this behaviorally defined functional network. Removal of high degree nodes produced the greatest network disruption (e.g., reduction in global efficiency). To test these predictions in vivo, we examined the impact of post-training chemogenetic silencing of different network nodes on fear memory consolidation. In a series of independent experiments encompassing 25% of network nodes (i.e., 21/84 brain regions), we found that node degree accurately predicted observed deficits in memory consolidation, with silencing of highly connected hubs producing the largest impairments.
Data from: Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's Disease - implications for space travel
- 负责人：
- Vlkolinsky, Roman
- 关键词：
- Mice Electrophysiology Animal behavior Protons Hippocampus Brain electrophysiology Alzheimer's disease Cytokines
- DOI：
- doi:10.5061/dryad.0008d
- 摘要：
- d not affect their behavioral performance, but reduced the amplitudes of population spikes and inhibited paired-pulse facilitation in CA1 neurons. These
Studies of intracellular cascades mediating neuronal damage in two animal models of neurodegeneration
- 负责人：
- DOI：
- doi:10.25549/usctheses-c3-335637
- 摘要：
- in drebrin and PTEN levels throughout the hippocampus. It was also associated with increased mTOR and Arc levels in fields CA1 and CA3 4 h after seizure
