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Data from: A major gene for bovine ovulation rate
- 负责人：
- DOI：
- doi:10.5061/dryad.66s7c
- 摘要：
- Half-sib daughters sired by a bull believed to be a carrier of a major gene for high ovulation rate were evaluated for ovulation rate and genotyped in an effort to both test the hypothesis of segregation of a major gene and to map the gene’s location. A total of 131 daughters were produced over four consecutive years at a University of Wisconsin-Madison research farm. All were evaluated for ovulation rate over an average of four estrous cycles using transrectal ultrasonography. The sire and all daughters were genotyped using a 3K SNP chip and the genotype and phenotype data were used in a linkage analysis. Subsequently, daughters recombinant within the QTL region and the sire were genotyped successively with 50K and 777K SNP chips to refine the location of the causative polymorphism. Positional candidate genes within the fine-mapped region were examined for polymorphism by Sanger sequencing of PCR amplicons encompassing coding and 5’ and 3’ flanking regions of the genes. Sire DNA was used as template in the PCR reactions. Strong evidence of a major gene for ovulation rate was observed (p<1x10-28) with the gene localized to bovine chromosome 10. Fine-mapping subsequently reduced the location to a 1.2 Mb region between 13.6 and 14.8 Mb on chromosome 10. The location identified does not correspond to that for any previously identified major gene for ovulation rate. This region contains three candidate genes, SMAD3, SMAD6 and IQCH. While candidate gene screening failed to identify the causative polymorphism, three polymorphisms were identified that can be used as a haplotype to track inheritance of the high ovulation rate allele in descendants of the carrier sire.
Data from: The dynamic role of genetics on cortical patterning during childhood and adolescence
- 负责人：
- DOI：
- doi:10.5061/dryad.5tp6r
- 摘要：
- Longitudinal imaging and quantitative genetic studies have both provided important insights into the nature of human brain development. In the present study we combine these modalities to obtain dynamic anatomical maps of the genetic contributions to cortical thickness through childhood and adolescence. A total of 1,748 anatomic MRI scans from 792 healthy twins and siblings were studied with up to eight time points per subject. Using genetically informative latent growth curve modeling of 81,924 measures of cortical thickness, changes in the genetic contributions to cortical development could be visualized across the age range at high resolution. There was highly statistically significant (P < 0.0001) genetic variance throughout the majority of the cerebral cortex, with the regions of highest heritability including the most evolutionarily novel regions of the brain. Dynamic modeling of changes in heritability over time demonstrated that the heritability of cortical thickness increases gradually throughout late childhood and adolescence, with sequential emergence of three large regions of high heritability in the temporal poles, the inferior parietal lobes, and the superior and dorsolateral frontal cortices.
Ovarian tumours in mice after X-ray and neutron exposure;;Link to data and details in ERA
- 负责人：
- 关键词：
- 500 science
- DOI：
- doi:10.20348/storedb/1076/1116
- 摘要：
- /min)Dosimetry: Twin ionization chamber method, ENDIPEndpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathologyAnimal: Female
Late somatic effects in mice after fractionated X-ray and neutron exposure;;Link to data and details in ERA
- 负责人：
- 关键词：
- 500 science
- DOI：
- doi:10.20348/storedb/1077/1117
- 摘要：
- ) from the biological facility of the RSV-TAPIRO reactor at CasacciaDosimetry: Twin ionization chamber method, ENDIPEndpoints: Life-span study (spontaneous
Long-term Survival and Tumor Induction After Exposure to High- and Low-LET Radiation;;Link to data and details in ERA
- 负责人：
- 关键词：
- 500 science
- DOI：
- doi:10.20348/storedb/1081/1121
- 摘要：
- n at a dose rate of 0.08 Gy/min, larger doses at 0.18 Gy/min) from the biological facility of the RSV-TAPIRO reactor at Casaccia.Dosimetry: Twin ionization chamber
Myeloid leukaemia and Harderian gland tumours in mice after X-ray and neutron exposure;;Link to data and details in ERA
- 负责人：
- 关键词：
- 500 science
- DOI：
- doi:10.20348/storedb/1078/1118
- 摘要：
- : Single exposure to 250 kVp X-rays (126 mGy/min, 1.5 mm HVL)Dosimetry: Twin ionization chamber ENDIPEndpoints: Life-span study (spontaneous death
Data from: Reducing early infant mortality in India: results of a prospective cohort of pregnant women utilizing emergency medical services
- 负责人：
- DOI：
- doi:10.5061/dryad.38n0n
- 摘要：
- rate (PMR) was 53 per 1000. Preterm birth [OR: 2.89, 95% CI: 1.67-5.00], twin deliveries (OR: 2.80, 95% CI: 1.10-7.15), and cesarean section (2.21, 95% CI
Data from: Trade-offs in lactation and milk intake by competing siblings in a fluctuating environment
- 负责人：
- DOI：
- doi:10.5061/dryad.0m068
- 摘要：
- transfer was independent of nursing frequency in females above median rank and higher for singletons than cubs in twin litters. Dominant siblings achieved
Data from: Twin introductions by independent invader mussel lineages are both associated with recent admixture with a native congener in Australia
- 负责人：
- DOI：
- doi:10.5061/dryad.540cc05
- 摘要：
- Introduced species can impose profound impacts on the evolution of receiving communities with which they interact. If native and introduced taxa remain reproductively semi-isolated, human-mediated secondary contact may promote genetic exchange across newly created hybrid zones, potentially impacting native genetic diversity and invasive species spread. Here, we investigate the contributions of recent divergence histories and ongoing (post-introduction) gene flow between the invasive marine mussel, Mytilus galloprovincialis and a morphologically indistinguishable and taxonomically contentious native Australian taxon, Mytilus planulatus. Using transcriptome-wide markers, we demonstrate that two contemporary M. galloprovincialis introductions into southeastern Australia originate from genetically divergent lineages from its native range in the Mediterranean Sea and Atlantic Europe, where both introductions have led to repeated instances of admixture between introduced and endemic populations. Through increased genome-wide resolution of species relationships, combined with demographic modelling, we validate that mussels sampled in Tasmania are representative of the endemic Australian taxon (M. planulatus), but share strong genetic affinities to M. galloprovincialis. Demographic inferences indicate late-Pleistocene divergence times and historical gene flow between the Tasmanian endemic lineage and northern M. galloprovincialis, suggesting that native and introduced taxa have experienced a period of historical isolation of at least 100,000 years. Our results demonstrate that many genomic loci and sufficient sampling of closely related lineages in both sympatric (e.g., Australian populations) and allopatric (e.g., northern-hemisphere Mytilus taxa) ranges are necessary to accurately (i) interpret patterns of intraspecific differentiation and to (ii) distinguish contemporary invasive introgression from signatures left by recent divergence histories in high dispersal marine species. More broadly, our study fills a significant gap in systematic knowledge of native Australian biodiversity and sheds light on the intrinsic challenges for invasive species research when native and introduced species boundaries are not well-defined.
Midlife in the United States (MIDUS 2): Cognitive Project, 2004-2006;;Version 1
- 负责人：
- 关键词：
- DOI：
- doi:10.3886/icpsr25281.v1
- 摘要：
- ) for the cognitive assessments were: Main RDD -- 85 percent, Sibling -- 92 percent, Twin -- 87 percent, and Milwaukee -- 52 percent.;;Datasets: \t\t\t\t\t\t\t\t\t\t\tDS1
