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Data from: Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates
- 负责人：
- DOI：
- doi:10.5061/dryad.4k887
- 摘要：
- on of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals and the existence
Data from: Exploring the selective constraint on the sizes of insertions and deletions in 5’ untranslated regions in mammals
- 负责人：
- DOI：
- doi:10.5061/dryad.vh3dm
- 摘要：
- regulatory elements are present. Results: We design the Indel Selection Index to measure the selective constraint on non-3n indels in 5'UTRs. The index controls
Data from: Gene expression levels are correlated with synonymous codon usage, amino acid composition and gene architecture in the red flour beetle
- 负责人：
- 关键词：
- translational selection;gene structure;size\/complexity score;Tribolium castaneum;tRNA abundance
- DOI：
- doi:10.5061/dryad.r0t1q
- 摘要：
- expression on synonymous codon usage, amino acid composition and gene structure in the red flour beetle, Tribolium castaneum. Consistent with the action of translational selection
Data from: A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus
- 负责人：
- DOI：
- doi:10.5061/dryad.1jn88
- 摘要：
- , genes maximally expressed at each stage display selection for codons that are most accurate given stage-specific queuosine modificati
Data from: TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogra
- 负责人：
- Kurimoto, Emi
- 关键词：
- Monkeys Cognitive impairment Alzheimer's disease Electroencephalography Biomarkers Animal cognition Cholinergics Oral administration
- DOI：
- doi:10.5061/dryad.qp313np
- 摘要：
- by scopolamine, a non-selective muscarinic receptor antagonist, with reduced side effects on gastrointestinal function in rats. In this study, we explored change
Data from: Cell death and survival due to cytotoxic exposure modeled as a two-state Ising system
- 负责人：
- DOI：
- doi:10.5061/dryad.4qrfj6q6d
- 摘要：
- nt to judiciously choose a drug type, its dosage, and schedule for optimized drug selection and administration. Consequently, the precise mathematical formulati
LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
- 负责人：
- Eidarus Salah;;Beltrami, Alessandra;;Apirat Chaikuad;;Hanke, Thomas;;Kashima, Risa;;Canning, Peter;;Knapp, Susanne Muller;;Knaus, Petra;;Hata, Akiko
- DOI：
- doi:10.5287/bodleian:zg5naqjyk
- 摘要：
- Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signal
Human Lim Domain Kinase 1 (Limk1), Kinase Domain; A Target Enabling Package
- 负责人：
- 关键词：
- protein target enabling package disease structure cancer neuropsychiatry neuro neurological genetic disorders metabolic diseases oncology
- DOI：
- doi:10.5281/zenodo.1287260
- 摘要：
- Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signal
Human Lim Domain Kinase 1 (Limk1), Kinase Domain; A Target Enabling Package
- 负责人：
- 关键词：
- protein target enabling package disease structure cancer neuropsychiatry neuro neurological genetic disorders metabolic diseases oncology
- DOI：
- doi:10.5281/zenodo.1241027
- 摘要：
- Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signal
Human LIM domain kinase 1 (LIMK1), kinase domain; A Target Enabling Package
- 负责人：
- 关键词：
- protein target enabling package disease structure cancer neuropsychiatry neuro neurological genetic disorders metabolic diseases oncology
- DOI：
- doi:10.5281/zenodo.1219706
- 摘要：
- Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signal
