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共检索到61条 ,权限内显示50条;
Data from: Antibiotic uptake across gram-negative outer membranes: better predictions towards better antibiotics
- 负责人:
- 关键词:
- outer membrane vesicles;molecular dynamics simulation;outer membrane porins;membrane permeability
- DOI:
- doi:10.5061/dryad.vdncjsxq1
- 摘要:
- of a wide variety of small molecules will enable simpler determination of which molecular scaffolds and which derivatives are most promising prior
Data from: Morphology, molecules, and the phylogenetics of cetaceans
- 负责人:
- DOI:
- doi:10.5061/dryad.62
- 摘要:
- of the molecular tree is sensitive to choice of artiodactyl outgroup taxa and the treatment of two small but ambiguously aligned regions of the 12S and 16S sequences
Data from: Small RNAs from a big genome: the piRNA pathway and transposable elements in the salamander species Desmognathus fuscus
- 负责人:
- Mueller, Rachel L.
- 关键词:
- genome size evolution small RNA evolution transposable element silencing piRNA pathway salamanders vertebrates
- DOI:
- doi:10.5061/dryad.kv57r
- 摘要:
- ross the Tree of Life, novel TE insertions are suppressed by several pathways involving small RNA molecules. In most known animals, TE activity in the germline is prima
Data from: Direct sequencing of haplotypes from diploid individuals through a modified emulsion PCR-based single-molecule sequencing approach
- 负责人:
- 关键词:
- Eurtytemora affinis
- DOI:
- doi:10.5061/dryad.rh7f4
- 摘要:
- in the PCR reaction, allowing easy identification and separation of individually amplified DNA molecules. We demonstrate the use of this method on a highly polymo
Data from: Comparison of methods for molecular species delimitation across a range of speciation scenarios
- 负责人:
- DOI:
- doi:10.5061/dryad.739bs
- 摘要:
- molecular approaches for species delimitation. Among the most widely used methods, the generalized mixed Yule-coalescent (GMYC) and Poisson tree processes (PTP) wer
Development of targeted therapies for peroxisome biogenesis disorders
- 负责人:
- 关键词:
- Molecular Biology peroxisome biogenesis disorders peroxins PEX1 high-content screening small molecules induced pluripotent stem cells HepG2 cells Pex1-p.G844D mouse
- DOI:
- doi:10.25549/usctheses-c40-298640
- 摘要:
- small molecules we identified could provide tools for investigating peroxisome biogenesis and novel leads for the development of targeted small molecule therapies
Data from: A next-generation sequencing approach to river biomonitoring using benthic diatoms
- 负责人:
- DOI:
- doi:10.5061/dryad.3gm8c
- 摘要:
- contained a smaller percentage of species from tropical (27.1–38.1%) than from temperate samples (53.7–77.8%). Agreement between morphological and molecular
Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
- 负责人:
- DOI:
- doi:10.5061/dryad.mb463
- 摘要:
- nd molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-res
Data from: Regulation of reproductive processes with Dynamic Energy Budgets
- 负责人:
- DOI:
- doi:10.5061/dryad.58j9r88
- 摘要:
- 1. Linking organismal level processes to underlying suborganismal mechanisms at the molecular, cellular and organ level constitutes a major chal
Data from: Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis
- 负责人:
- DOI:
- doi:10.5061/dryad.qg04542
- 摘要:
- -/-), showing significant increases in paracellular BBB permeability to small molecules without structural changes in junctional complexes bet