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Data from: The causes of epistasis in genetic networks
- 负责人：
- DOI：
- doi:10.5061/dryad.7nf24
- 摘要：
- n organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from posi
Data from: Negative epistasis between beneficial mutations in an evolving bacterial population
- 负责人：
- DOI：
- doi:10.5061/dryad.5rv40
- 摘要：
- d the opposite effect. These data support models in which negative epistasis contributes to declining rates of adaptation over time. Sign epistasis was rare
Data from: Widespread genetic incompatibilities between first-step mutations during parallel adaptation of Saccharomyces cerevisiae to a common
- 负责人：
- DOI：
- doi:10.5061/dryad.vs370
- 摘要：
- of mutations causing lower growth when combined in a double mutant than when alone as a single mutant (sign epistasis). The prevalence of sign epistasis
Data from: Epistasis buffers the fitness effects of rifampicin-resistance mutations in Pseudomonas aeruginosa
- 负责人：
- DOI：
- doi:10.5061/dryad.8858
- 摘要：
- rally smaller than that predicted from the effects of individual mutations on the wild type. Second, we show that sign epistasis between resistance muta
Data from: Mapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations
- 负责人：
- 关键词：
- Experimental evolution;epistasis;Adaptation;fitness landscape;Metabolism;Methylobacterium extorquens
- DOI：
- doi:10.5061/dryad.8hb23
- 摘要：
- bolism of Methylobacterium extorquens to uncover the fitness landscape defined by gene expression levels. We found strong antagonism and sign epistasis between these beneficial muta
Data from: Selection biases the prevalence and type of epistasis along adaptive trajectories
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.f468j
- 摘要：
- ter, with a concomitant shift from predominantly antagonistic interactions early in adaptation to synergistic and sign epistasis later in adaptation. We observe the sam
Data from: The impact of high-order epistasis in the within-host fitness of a positive-sense plant RNA virus
- 负责人：
- DOI：
- doi:10.5061/dryad.6hq65
- 摘要：
- of multiple peaks and holes in the landscape. We found prevailing epistatic effects between mutations, with cases of reciprocal sign epistasis being common amo
Data from: Sign epistasis limits evolutionary trade-offs at the confluence of single- and multi-carbon metabolism in Methylobacterium extorquens AM1
- 负责人：
- DOI：
- doi:10.5061/dryad.n2645
- 摘要：
- on S, as it was neutral or even deleterious in certain evolved lineages that remained M+. This suggests that sign epistasis with earlier arising mutations prevented
Data from: Robustness to noise in gene expression evolves despite epistatic constraints in a model of gene networks
- 负责人：
- DOI：
- doi:10.5061/dryad.8c81j
- 摘要：
- do allow the gradual evolution of increased robustness. Despite strong sign epistasis, adaptation rarely proceeds via deleterious intermediate steps
Data from: A shift from magnitude to sign epistasis during adaptive evolution of a bacterial social trait
- 负责人：
- DOI：
- doi:10.5061/dryad.1c617
- 摘要：
- While the importance of epistasis in evolution has long been recognized, remarkably little is known about the processes by which
