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Data from: The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi
- 负责人：
- DOI：
- doi:10.5061/dryad.h44t1
- 摘要：
- Malaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy. Evolutionary theorists have raised the possibility tha
Data from: The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection
- 负责人：
- DOI：
- doi:10.5061/dryad.853nh
- 摘要：
- asites can have profound effects on the evolution of drug resistance. Here, using the Plasmodium chabaudi mouse malaria model, we ask whether
Data from: Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites
- 负责人：
- DOI：
- doi:10.5061/dryad.4h0g0
- 摘要：
- competitive release. Using the rodent malaria model Plasmodium chabaudi, we found that low-dose chemotherapy did reduce competitive release. A higher drug dose regimen
Data from: Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring
- 负责人：
- DOI：
- doi:10.5061/dryad.v244v
- 摘要：
- ded to identify a meaningful increase in infection half-life. Here, we show that five previously unexposed genotypes of the rodent malaria par
Data from: Costs of crowding for the transmission potential in malaria parasites
- 负责人：
- DOI：
- doi:10.5061/dryad.44jf2
- 摘要：
- ensity of rodent malaria (Plasmodium berghei) infections in Anopheles stephensi mosquitoes under different environmental conditions, we show that parasites experience
Antimalarial activity, toxicity, pharmacokinetics and metabolic drug interaction of Plumbago Indica linn.
- 负责人：
- Kesara Na-Bangchang, Advisor
- 关键词：
- Plumbagin Antimalarial Plasmodium falciparum Plasmodium berghei Permeability Transport Efflux transporters Caco-2 cell P-glycoprotein Pharmacokinetics
- DOI：
- doi:10.14457/tu.the.2015.159
- 摘要：
- (270-490) nM, respectively. In vivo antimalarial activity was investigated in Plasmodium berghei infected mouse model. Chloroquine exhibited the mos
Data from: The impact of within-host ecology on the fitness of a drug-resistant parasite
- 负责人：
- 关键词：
- rodent malaria;fitness cost;within-host competition;Drug resistance;malaria;Plasmodium chabaudi
- DOI：
- doi:10.5061/dryad.1g2n6d2
- 摘要：
- when resistance was rarer to begin with. Methodology: We infected mice with varying densities of drug-resistant Plasmodium chabaudi malaria parasites in a fixed
Data from: Opportunities and challenges of Integral Projection Models for modeling host-parasite dynamics
- 负责人：
- 关键词：
- Integral Projection Model parasite demography infectious disease dynamics murine malaria measles
- DOI：
- doi:10.5061/dryad.07mc1
- 摘要：
- categorization and/or agent-based approaches. Integral Projection Models (IPMs) allow variance in individual trajectories of quantitative traits and thei
Data from: Adaptive periodicity in the infectivity of malaria gametocytes to mosquitoes
- 负责人：
- DOI：
- doi:10.5061/dryad.g0j11kf
- 摘要：
- , this may select for rhythms in immune defence. We examine rhythms in the density and infectivity of transmission forms (gametocytes) of rodent malaria par
Data from: Aggressive chemotherapy and the selection of drug resistant pathogens
- 负责人：
- DOI：
- doi:10.5061/dryad.09qc0
- 摘要：
- in vivo in conjunction with measures of clinical outcomes and infectiousness. Using rodent malaria in laboratory mice, we found that less aggressive
