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Data from: Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle
- 负责人：
- DOI：
- doi:10.5061/dryad.s3443
- 摘要：
- a novel method called rapid quantitative pharmacodynamic imaging. This method combines pharmacokinetic-pharmacodynamic modeling, repeated small doses
Data from: Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and r
- 负责人：
- Lammens, Lieve
- DOI：
- doi:10.5061/dryad.5vv774m
- 摘要：
- ous solid dispersion (ASD) formulation was developed. As this formulation results in improved systemic absorption, the pharmacokinetic and toxicological profile
Data from: Developmental expression of drug metabolizing enzymes: impact on disposition in neonates and young children
- 负责人：
- DOI：
- doi:10.5061/dryad.71pp6
- 摘要：
- -dependent changes in other physiological factors impacting drug disposition, can be integrated into physiologically-based pharmacokinetic models. Such models ha
Data from: Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy
- 负责人：
- DOI：
- doi:10.5061/dryad.g003051
- 摘要：
- Objective To report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated pati
Data from: Targeting antibiotic resistant bacteria with phages reduces bacterial density in an insect host
- 负责人：
- Mikonranta, Lauri
- DOI：
- doi:10.5061/dryad.sc54383
- 摘要：
- d pharmacokinetic effects on both phage and antibiotic dynamics compared to in vitro: antibiotics did not reduce the overall amount of bacteria, demonstrati
Data from: Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors
- 负责人：
- DOI：
- doi:10.5061/dryad.4h76d
- 摘要：
- mechanisms that govern their capture by the target cell. Next-generation pharmacokinetic (PK) models that systematically account for proteomic and mechanic
Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis
- 负责人：
- DOI：
- doi:10.5061/dryad.4hk2039
- 摘要：
- Myasthenia Gravis Quality of Life scale), pharmacokinetics, pharmacodynamics, and immunogenicity. Results: Of the 35 screened patients, 24 were enrolled and r
Data from: Spectroscopic and molecular docking studies reveal binding characteristics of nazartinib (EGF816) to human serum albumin
- 负责人：
- DOI：
- doi:10.5061/dryad.05c6v93
- 摘要：
- tely gained considerable attention due to the significant influence of such interactions on the pharmacokinetics and/or -dynamics of this important class
Antimalarial activity, toxicity, pharmacokinetics and metabolic drug interaction of Plumbago Indica linn.
- 负责人：
- Kesara Na-Bangchang, Advisor
- 关键词：
- Pharmacokinetics Plumbagin Antimalarial Plasmodium falciparum Plasmodium berghei Permeability Transport Efflux transporters Caco-2 cell P-glycoprotein
- DOI：
- doi:10.14457/tu.the.2015.159
- 摘要：
- the pharmacokinetics and disposition of plumbagin in animal model.Results suggest that clinical relevance of the interference of human drug metabolizing enzymes should
Proinsulin-transferrin fusion protein as a liver targeting insulin therapeutic in Type 1 diabetes treatment
- 负责人：
- 关键词：
- Pharmaceutical Sciences proinsulin-transferrin fusion protein liver targeting diabetes long-acting insulin therapeutic
- DOI：
- doi:10.25549/usctheses-c40-250950
- 摘要：
- nd. ? Among a myriad of efforts in optimizing pharmacokinetic and pharmacodynamic (PK/PD) profiles of basal INS therapeutics, novel delivery devices applied
