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Data from: Mutation dynamics and fitness effects followed in single cells
- 负责人：
- DOI：
- doi:10.5061/dryad.75625
- 摘要：
- of single cells, accumulating ~20,000 mutations genome-wide over hundreds of generations. This analysis revealed that 1% of mutations were lethal; nonlethal
Data from: Population persistence under high mutation rate: from evolutionary rescue to lethal mutagenesis
- 负责人：
- DOI：
- doi:10.5061/dryad.n7c08t7
- 摘要：
- evolutionary rescue. However, larger increase leads to extinction by the accumulation of a large mutation load, a process called lethal mutagenesis. We discuss
Data from: The fitness cost of mismatch repair mutators in Saccharomyces cerevisiae: partitioning the mutational load
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.4b10j7q
- 摘要：
- to estimate the load due to lethal mutations (i.e. the lethal mutation rate), we manipulate thousands of individual pairs of mother and daughter cells and track
Data from: The balanced-lethal system of crested newts: a ghost of sex chromosomes past?
- 负责人：
- DOI：
- doi:10.5061/dryad.3n977
- 摘要：
- Balanced lethal systems are more than biological curiosities: As theory predicts, they should quickly be eliminated through the joint forces
Data from: Sub-lethal effects on fish provide insight into a biologically-relevant threshold of hypoxia
- 负责人：
- DOI：
- doi:10.5061/dryad.td771
- 摘要：
- h definitions may be too conservative, as ecologically-relevant non-lethal effects (e.g. consumption and growth) of hypoxia on important aquatic species, suc
Data from: The impact of high-order epistasis in the within-host fitness of a positive-sense plant RNA virus
- 负责人：
- DOI：
- doi:10.5061/dryad.6hq65
- 摘要：
- during the experimental adaptation of the virus to the novel host Arabidopsis thaliana. Fitness was measured for many genotypes, and showed the existence
Data from: Evolutionary rescue of sexual and asexual populations in a deteriorating environment
- 负责人：
- DOI：
- doi:10.5061/dryad.6df73
- 摘要：
- diversity lines had occurred by mid-way through the experiment, indicating that positive genetic correlations of adaptation to lethal stress with adaptati
Data from: Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome
- 负责人：
- 关键词：
- synaptic transmission;Neuromuscular Disease;congenital myasthenic syndrome;drosophila melanogaster
- DOI：
- doi:10.5061/dryad.st621
- 摘要：
- ve synaptotagmin, this mutation is lethal, demonstrating for the first time that this residue plays a critical role in synaptotagmin function. To achieve expression
Data from: Genetic Allee effects and their interaction with ecological Allee effects
- 负责人：
- Wittmann, Meike
- 关键词：
- conservation genetics critical density extinction vortex invasion biology lethal mutation persistence population viability positive density dependence purging stochastic simulation
- DOI：
- doi:10.5061/dryad.pv910
- 摘要：
- lee effect, but only if individuals carry sufficiently many deleterious mutations (lethal equivalents). Populations suffering from a genetic Allee effect often first grow, then decline
Data from: Blood mercury levels of zebra finches are heritable: implications for the evolution of mercury resistance
- 负责人：
- Swaddle, John P.
- DOI：
- doi:10.5061/dryad.17483
- 摘要：
- Mercury is a ubiquitous metal contaminant that negatively impacts reproduction of wildlife and has many other sub-lethal effects. Songbirds ar
