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Data from: The causes of epistasis in genetic networks
- 负责人：
- DOI：
- doi:10.5061/dryad.7nf24
- 摘要：
- Epistasis refers to the non-additive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a give
Data from: Negative epistasis between beneficial mutations in an evolving bacterial population
- 负责人：
- DOI：
- doi:10.5061/dryad.5rv40
- 摘要：
- the epistatic effect. Epistasis thus tended to produce diminishing returns with genotype fitness, although interactions involving one particular mutation ha
Data from: Diminishing-returns epistasis among random beneficial mutations in a multicellular fungus
- 负责人：
- DOI：
- doi:10.5061/dryad.6fb43
- 摘要：
- epistasis) may affect the dynamics and repeatability of adaptation. However, understanding the importance and implications of epistasis is hampered
Data from: Positive epistasis drives the acquisition of multidrug resistance.
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.20k7j
- 摘要：
- of resistance to multiple drugs depends both on their costs individually and on how they interact—epistasis. Information on the level of epistasis bet
Data from: Effects of epistasis on infectivity range during host-parasite coevolution
- 负责人：
- DOI：
- doi:10.5061/dryad.25kn0
- 摘要：
- kely to arise simultaneously. A key, but as yet unexplored factor is precisely how interactions between mutations (epistasis) affect parasite evolution. Her
Data from: Epistasis buffers the fitness effects of rifampicin-resistance mutations in Pseudomonas aeruginosa
- 负责人：
- DOI：
- doi:10.5061/dryad.8858
- 摘要：
- . First, we show that epistasis between rifampicin-resistance mutations tends to be antagonistic: the fitness effect of having two mutations is gene
Data from: Strong selection significantly increases epistatic interactions in the long-term evolution of a protein
- 负责人：
- DOI：
- doi:10.5061/dryad.q66s5
- 摘要：
- in the long-term evolution of a protein. Here we analyze the evolution of epistasis in the protease of the human immunodeficiency virus type 1 (HIV-1) using protease
Data from: Detecting epistasis from an ensemble of adapting populations
- 负责人：
- DOI：
- doi:10.5061/dryad.0hm4r
- 摘要：
- The role that epistasis plays during adaptation remains an outstanding problem, which has received considerable attention in recent years. Mos
Data from: Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species
- 负责人：
- DOI：
- doi:10.5061/dryad.qn370
- 摘要：
- , demonstrating that epistatic interactions between rpoB and the rest of the genome are common. Moreover, epistasis is typically strong, and it is the dominant gene
Data from: Selection biases the prevalence and type of epistasis along adaptive trajectories
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.f468j
- 摘要：
- of epistasis in most organisms, recent experiments with bacterial populations have concluded that antagonistic interactions abound and tend to de-accelerate
