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Data from: Early antiretroviral therapy and potent second-line drugs could decrease HIV incidence of drug resistance
- 负责人：
- DOI：
- doi:10.5061/dryad.3v9h5
- 摘要：
- incidence of ART initiation timing, frequency of acquired drug resistance, and second-line drug effectiveness (defined as the combination
Data from: Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites
- 负责人：
- DOI：
- doi:10.5061/dryad.4h0g0
- 摘要：
- of resistant parasites. Here, we test the hypothesis that the spread of resistance can be slowed by reducing drug treatment and hence res
Data from: Generalized polyspike train: an EEG biomarker of drug-resistant idiopathic generalized epilepsy
- 负责人：
- 关键词：
- epilepsy;EEG
- DOI：
- doi:10.5061/dryad.51d718j
- 摘要：
- Objective: To identify clinical and EEG biomarkers of drug resistance in adults with idiopathic generalized epilepsy. Methods: We conducted
Data from: Resource limitation prevents the emergence of drug resistance by intensifying within-host competition
- 负责人：
- DOI：
- doi:10.5061/dryad.v2q3v
- 摘要：
- of malaria infection, we show that limiting a resource that is disproportionately required by resistant parasites retards the evolution of drug resistance
Data from: Aggressive chemotherapy and the selection of drug resistant pathogens
- 负责人：
- DOI：
- doi:10.5061/dryad.09qc0
- 摘要：
- Drug resistant pathogens are one of the key public health challenges of the 21st century. There is a widespread belief that resistance is bes
Data from: The impact of within-host ecology on the fitness of a drug-resistant parasite
- 负责人：
- 关键词：
- rodent malaria;fitness cost;within-host competition;Drug resistance;malaria;Plasmodium chabaudi
- DOI：
- doi:10.5061/dryad.1g2n6d2
- 摘要：
- Background and objectives: The rate of evolution of drug resistance depends on the fitness of resistant pathogens. The fitness of resistant pathogens
Data from: Exposure to phages has little impact on the evolution of bacterial antibiotic resistance on drug concentration gradients
- 负责人：
- DOI：
- doi:10.5061/dryad.f9h64
- 摘要：
- in antibiotic-resistant bacteria, although it did so in antibiotic-susceptible bacteria. We observed significant reversion of antibiotic resistance after drug use being terminated
Data from: Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring
- 负责人：
- DOI：
- doi:10.5061/dryad.v244v
- 摘要：
- infections may signal developing resistance to treatment. In the absence of molecular markers for resistance, current efforts to monitor drug efficacy ar
Data from: Does high-dose antimicrobial chemotherapy prevent the evolution of resistance?
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.fs950
- 摘要：
- High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies hav
Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
- 负责人：
- DOI：
- doi:10.5061/dryad.mb463
- 摘要：
- Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant
