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Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis
- 负责人：
- 关键词：
- Microbiology Cell Biology Molecular Biology Physiology 59999 Environmental Sciences not elsewhere classified Ecology Science Policy Immunology Cancer Science Policy
- DOI：
- doi:10.6084/m9.figshare.1601892.v1
- 摘要：
- mechanism linking wear particles to osteoblast apoptosis remains almost totally unknown. In the present study, we investigated the effect of autophagy
Data from: Acute, delayed and chronic remote ischemic conditioning is associated with downregulation of mTOR and enhanced autophagy signaling
- 负责人：
- DOI：
- doi:10.5061/dryad.44jk0
- 摘要：
- rotection and its underlying mediators and mechanisms remains incomplete. In this study we examine the effect of RIC on pro- autophagy signaling as a possible mecha
Data from: Novel roles of chloroquine and hydroxychloroquine in Graves’ orbitopathy therapy by targeting orbital fibroblasts
- 负责人：
- DOI：
- doi:10.5061/dryad.5tb2rbp1k
- 摘要：
- lmos by inducing excessive proliferation, adipogenesis and glycosaminoglycan production in orbital fibroblasts (OFs). Interference with OF autophagy is a potential
h increased autophagy
- 负责人：
- DOI：
- doi:10.5061/dryad.2gn8c
- 摘要：
- p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate
Data from: Investigation of discriminant metabolites in tamoxifen-resistant and choline kinase-alpha-downregulated breast cancer cells using 1H
- 负责人：
- 关键词：
- 1H-NMR
- DOI：
- doi:10.5061/dryad.64f8c
- 摘要：
- Metabolites linked to changes in choline kinase-? (CK-?) expression and drug resistance, which contribute to survival and autophagy mechanisms, ar
Data from: Elovanoids counteract oligomeric ?-Amyloid-induced gene expression and protect photoreceptors
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.59zw3r233
- 摘要：
- ?-induced changes in gene expression engaged in senescence, inflammation, autophagy, extracellular matrix remodeling and AMD. Moreover, since OA? target
Data from: Agonist-specific voltage-dependent gating of lysosomal Two-Pore Na + Channels
- 负责人：
- DOI：
- doi:10.5061/dryad.s5f6j9h
- 摘要：
- of the cell biological roles of TPCs, and can also readily explain the reported effects of TCAs in the modulation of autophagy and lysosomal function.
Data from: Selective sets of mRNAs localize to extracellular paramural bodies in the rice glup6 mutant line
- 负责人：
- Okita, Thomas W.
- 关键词：
- DOI：
- doi:10.5061/dryad.sn878g4
- 摘要：
- specific autophagy is also an alternative mechanism, these studies support the view that RNA localization may co-opt membrane vesicular trafficking and tha
Data from: Screen for mitochondrial DNA copy-number maintenance genes reveals essential role for ATP synthase
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.v55p5
- 摘要：
- production, followed by copy number depletion involving increased mitochondrial turnover, not dependent on the canonical autophagy machinery. Our findings will inform
Data from: Long-lived rodents reveal signatures of positive selection in genes associated with lifespan
- 负责人：
- Sahm, Arne
- 关键词：
- Positive selection African mole-rats Naked mole-rat Evolution of longevity lifespan Blind mole rat Spalax IGF1 RHEB RHEBL1
- DOI：
- doi:10.5061/dryad.75b406n
- 摘要：
- : translation, autophagy and inflammation. Remarkably, among PSGs are RHEB, a regulator of mTOR, and IGF1, both central components of aging-relevant pathways
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