Data from: Mirrored STDP implements autoencoder learning in a network of spiking neurons

负责人：

关键词：

DOI：

doi:10.5061/dryad.kv5r4

摘要：

rules at feedforward versus feedback connections are temporally opposed versions of spike-timing dependent plasticity (STDP), leading to a symmetric

Water quality data for Fall Creek (Tompkins County, NY) sampling sites: 1972-1995

负责人：

关键词：

streams, watersheds, stream flow, water pollution, water quality, water pH, agricultural pollution, sediment pollution, alkalinity, calcium, cations, anions, magnesium, chlorides, sulfates, potassium, sodium, nitrates, nitrogen, ammonium compounds, phosphorus Fall Creek Tompkins County, NY Fertilizers, Discharge\/Flow, Rivers\/Streams, Surface Water Chemistry, pH, Alkalinity, Nitrogen Compounds, Nutrients, Phosphorous Compounds, Water Ion Concentration, Suspended Solids

DOI：

doi:10.5063/aa/gss1.12.1

摘要：

with land runoff and the lakes in central NY. Major findings follow. Three P fractions were measured: MRP, TDP and TP. MRP was measured on filtered samples

Water quality data for Fall Creek (Tompkins County, NY) sampling sites: 1972-1995

负责人：

关键词：

streams watersheds stream flow water pollution water quality water pH agricultural pollution sediment pollution alkalinity calcium

DOI：

doi:10.5063/aa/gss1.12.16

摘要：

with land runoff and the lakes in central NY. Major findings follow. Three P fractions were measured: MRP, TDP and TP. MRP was measured on centrifuged samples

Data from: Postmortem neurodegenerative markers and trajectories of decline in cognitive systems

负责人：

关键词：

Cognitive neuropsychology in dementia;Cohort studies;Natural history studies (prognosis);Alzheimer's disease;Dementia with Lewy bodies

DOI：

doi:10.5061/dryad.mf7hk2q

摘要：

, they underwent a neuropathologic examination to quantify Alzheimer’s disease (AD) pathology, Lewy bodies, transactive response DNA-binding protein 43 (TDP-43

Data from: Watershed versus within-lake drivers of nitrogen: phosphorus dynamics in shallow lakes

负责人：

Zimmer, Kyle

关键词：

alternative stable states nutrient limitation eutrophication nutrient stoichiometry N:P ratio denitrification

DOI：

doi:10.5061/dryad.6b650

摘要：

e (turbid versus clear) on total N: total P (TN:TP), ammonium, total dissolved phosphorus (TDP), and seston stoichiometry. We also examined N:P stoichiometry

Data from: Human-dominated land uses favour species affiliated with more extreme climates, especially in the tropics

负责人：

关键词：

DOI：

doi:10.5061/dryad.c2fqz6149

摘要：

d in the paper. The columns for the CWMs of range-wide variation are headed CWM_STDTmax, CWM_STDTmin, CWM_STDPpmax and CWM_STDPpmin. The columns headed 'Total

Data from: Simultaneous determination of underivatized vitamin B1 and B6 in whole blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass spectrometry

负责人：

关键词：

TDP;Tandem MS;PLP;UHPLC-MSMS;Vitamin B1 and B6

DOI：

doi:10.5061/dryad.2sq12

摘要：

Background: Vitamin B1 (thiamine-diphosphate) and B6 (pyridoxal-5’phosphate) are micronutrients. Analysis of these micronutrients is important to diagnose potential deficiency which often occurs in elderly people due to malnutrition, in severe alcoholism and in gastrointestinal compromise due to bypass surgery or disease. Existing High Performance Liquid Chromatography (HPLC) based methods include the need for derivatization and long analysis time. We developed an Ultra High Performance Liquid Chromatography Tandem Mass spectrometry (UHPLC-MS/MS) assay with internal standards for simultaneous measurement of underivatized thiamine-diphosphate and pyridoxal-5’phosphate without use of ion pairing reagent. Methods: Whole blood, deproteinized with perchloric acid, containing deuterium labelled internal standards thiamine-diphosphate(thiazole-methyl-D3) and pyridoxal-5’phosphate(methyl-D3), was analyzed by UHPLC-MS/MS. The method was validated for imprecision, linearity, recovery and limit of quantification. Alternate (quantitative) method comparisons of the new versus currently used routine HPLC methods were established with Deming regression. Results: Thiamine-diphosphate and pyridoxal-5’phosphate were measured within 2.5 minutes instrumental run time. Limits of detection were 2.8 nmol/L and 7.8 nmol/L for thiamine-diphosphate and pyridoxal-5’phosphate respectively. Limit of quantification was 9.4 nmol/L for thiamine-diphosphate and 25.9 nmol/L for pyridoxal-5’phosphate. The total imprecision ranged from 3.5-7.7 % for thiamine-diphosphate (44-157 nmol/L) and 6.0-10.4 % for pyridoxal-5’phosphate (30-130 nmol/L). Extraction recoveries were 101-102% ± 2.5 % (thiamine-diphosphate) and 98-100 % ± 5 % (pyridoxal-5’phosphate). Deming regression yielded slopes of 0.926 and 0.990 in patient samples (n=282) and national proficiency testing samples (n=12) respectively, intercepts of +3.5 and +3 for thiamine-diphosphate (n=282 and n=12) and slopes of 1.04 and 0.84, intercepts of -2.9 and +20 for pyridoxal-5’phosphate (n=376 and n=12). Conclusion: The described UHPLC-MS/MS method allows simultaneous determination of underivatized thiamine-diphosphate and pyridoxal-5’phosphate in whole blood without intensive sample preparation.