Data from: Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species

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关键词：

Experimental evolution;epistasis;antibiotic resistance;genetic background;fitness costs

DOI：

doi:10.5061/dryad.qn370

摘要：

populations. We address this idea by measuring the fitness effect of a collection of rifampicin resistance mutations in the ? subunit of RNA polymerase (rpo

Data from: Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa

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关键词：

RNA polymerase mutations;pleiotropy;Antibiotic resistance mutations;Rifampicin resistance;Pseudomonas aeruginosa;Fitness cost of resistance

DOI：

doi:10.5061/dryad.vj35n

摘要：

c basis of resistance to its fitness cost remain poorly characterized. Here, we examine how the system-wide impacts of mutations in the RNA polymerase (RNAP) gene rpo

Data from: Compensatory mutations improve general permissiveness to antibiotic resistance plasmids

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关键词：

Experimental evolution;Pseudomonas sp. nov. H2;Multidrug resistance;Adaptation;Pseudomonas;Horizontal gene transfer;plasmid persistence;IncP-1 plasmid

DOI：

doi:10.5061/dryad.v25vk

摘要：

s and the RNA polymerase ?-subunit. Our and other findings suggest that poor plasmid persistence can be caused by a high cost involving helicase-plasmid interactions tha

Data from: Single-cell virus sequencing of influenza infections that trigger innate immunity

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关键词：

10X Chromium;defective virus;influenza virus;single-cell RNA-seq;Interferon;NS1;PacBio;PB1;Heterogeneity

DOI：

doi:10.5061/dryad.nh053c6

摘要：

on of the viral polymerase protein PB1, large internal deletions in viral genes, and failure to express the virus's interferon antagonist NS1. However, immune activati