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Data from: Revisiting protein aggregation as pathogenic in sporadic Parkinson’s and Alzheimer’s diseases
- 负责人：
- Espay, Alberto J.
- 关键词：
- Parkinson’s disease Alzheimer’s disease biomarkers disease modifying treatments clinical trials
- DOI：
- doi:10.5061/dryad.g1nq02r
- 摘要：
- is the assumption that pathological protein aggregation at autopsy reflect pathogenesis at disease onset. While these aggregates may in exceptional cas
Data from: A mix-and-click method to measure amyloid-? concentration with sub-micromolar sensitivity
- 负责人：
- DOI：
- doi:10.5061/dryad.7mg3h
- 摘要：
- Aggregation of amyloid-? (A?) protein plays a central role in Alzheimer's disease. Because protein aggregation is a concentration-dependent pro
Data from: Aging, mortality, and the fast growth trade-off of Schizosaccharomyces pombe
- 负责人：
- DOI：
- doi:10.5061/dryad.s2t5t
- 摘要：
- w-pole cells. We found that cell deaths were typically preceded by sudden acceleration of protein aggregation, thus relatively large amount of protein aggregates
Correlative Light and Electron Microscopy for the Investigation of Muscle Disease
- 负责人：
- 关键词：
- Genetics
- DOI：
- doi:10.4225/03/55babdb6578a9
- 摘要：
- , we created a zebrafish model. To generate the model we expressed a disease causing form of ACTA1 (ACTA1D286G) tagged with enhanced green fluorescent protein
Data from: Protein degradation rate in Arabidopsis thaliana leaf growth and development
- 负责人：
- DOI：
- doi:10.5061/dryad.q3h85
- 摘要：
- , while N-end amino acid, hydrophobicity or aggregation propensity of proteins were not. We discovered rapidly degrading subunits in a variety of protein
Data from: Evolution of altruistic cooperation among nascent multicellular organisms
- 负责人：
- DOI：
- doi:10.5061/dryad.tp5923t
- 摘要：
- through the creation of protein aggregates, only arising in strains with high (>2%) rates of cell death. Nonetheless, it was adaptive and r
Data from: Serum amyloid A protein concentration in blood is influenced by genetic differences in the cheetah (Acinonyx jubatus)
- 负责人：
- DOI：
- doi:10.5061/dryad.0nr72
- 摘要：
- Systemic amyloid A (AA) amyloidosis is a major cause of morbidity and mortality among captive cheetahs. The self-aggregating AA protein responsible
Data from: Site-specific structural order in Alzheimer’s A?42 fibrils
- 负责人：
- DOI：
- doi:10.5061/dryad.768dk4s
- 摘要：
- Deposition of amyloid fibrils is a pathological hallmark of Alzheimer’s disease. A?42 is the major protein whose aggregation leads to the formati
Data from: Oxidative stress-mediated NF?B phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival throug
- 负责人：
- DOI：
- doi:10.5061/dryad.2gn8c
- 摘要：
- p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate
Data from: A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.4g60032
- 摘要：
- and TERT inhibitors. The tert KO’s other defects (delayed aggregation, irregular streaming) were associated with changes to cAMP-regulated pro
