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Data from: Risky behaviors and Parkinson’s disease: a Mendelian randomization study
- 负责人：
- DOI：
- doi:10.5061/dryad.54t59r8
- 摘要：
- Objective: To examine causal associations between risky behavior phenotypes on Parkinson’s disease using a Mendelian randomization approach. Methods
Data from: Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs
- 负责人：
- Donner, Jonas
- DOI：
- doi:10.5061/dryad.dd91b
- 摘要：
- ng. Limited data on frequencies of genetic disease variants across breeds exists, and the disease heritage of mixed breed dogs remains poorly explored to dat
Data from: Relative effects of LDL-C on ischaemic stroke & coronary disease: a Mendelian randomization study
- 负责人：
- DOI：
- doi:10.5061/dryad.8076h3r
- 摘要：
- t for coronary heart disease (CHD) using a Mendelian randomization approach. Methods: We undertook a two-sample Mendelian randomization, based on summary data, to estimate the causal
Data from: Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
- 负责人：
- DOI：
- doi:10.5061/dryad.10r1pt0
- 摘要：
- Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying
Data from: Population-specific genetic modification of Huntington's disease in Venezuela
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.tg5f2hp
- 摘要：
- Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA
Data from: Direct-to-consumer DNA testing of 6,000 dogs reveals 98.6-kb duplication associated with blue eyes and heterochromia in Siberian Huskies
- 负责人：
- DOI：
- doi:10.5061/dryad.h305b15
- 摘要：
- singly complex traits, behaviors, and disease by including many thousands of individuals in genome-wide association studies (GWAS). The promise of consumer genomic data
Data from: Whole genome sequencing and rare variant analysis in essential tremor families
- 负责人：
- DOI：
- doi:10.5061/dryad.td8d20v
- 摘要：
- ) is likely to be of value in understanding a large proportion of ET with Mendelian and complex disease inheritance patterns. In ET famili
Data from: Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.pk50t
- 摘要：
- , and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG
Data from: Combining GWAS and RNA-seq approaches for detection of the causal mutation for hereditary junctional epidermolysis bullosa in sheep
- 负责人：
- 关键词：
- Junctional Epidermolysis Bullosa aplasia cutis congenita integrin beta-4 sheep association mapping whole skin transcriptomic analysis
- DOI：
- doi:10.5061/dryad.4j7jh
- 摘要：
- , as an efficient approach to detect the causal mutation for a Mendelian disease. Junctional epidermolysis bullosa is a recessive genodermatosis that manifests with neonatal
Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs
- 负责人：
- DOI：
- doi:10.5061/dryad.012s5
- 摘要：
- for amino acid changing variants and Mendelian disease genes. To our knowledge, these results provide the first quantitative estimates of the increased burden
