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Data from: Molecular mechanisms of 2, 3?, 4, 4?, 5-pentachlorobiphenyl-induced thyroid dysfunction in FRTL-5 cells
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.3479r
- 摘要：
- ly. Quantitative real-time polymerase chain reaction was used to quantify protein kinase B (Akt), Forkhead box protein O3a (FoxO3a), and sodium/iodide symporter (NIS) mRNA expression level
Data from: Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
- 负责人：
- DOI：
- doi:10.5061/dryad.75940
- 摘要：
- biosynthesis and critical weight. Here we elucidate a mechanism through which this occurs. We show that Forkhead Box class O (FoxO), a negative regulator of IIS
Data from: Longevity is determined by ETS transcription factors in multiple tissues and diverse species
- 负责人：
- DOI：
- doi:10.5061/dryad.5qv9750
- 摘要：
- signalling (IIS) extends lifespan by coordinating activation of Aop, an ETS transcriptional repressor, and Foxo, a Forkhead transcriptional activator. Aop
Data from: Insulin-insensitivity of male genitals maintains reproductive success in Drosophila
- 负责人：
- DOI：
- doi:10.5061/dryad.44bm68r
- 摘要：
- of the male genitalia is a consequence of low insulin sensitivity through a tissue-specific reduction in expression of FOXO, a negative growth regulator. Des
Data from: Adaptation to chronic nutritional stress leads to reduced dependence on microbiota in Drosophila melanogaster
- 负责人：
- Erkosar, Berra
- DOI：
- doi:10.5061/dryad.td3r1
- 摘要：
- populations became much less dependent on colonization with microbiota. This was accompanied by changes in expression levels of dFOXO transcription factor
Data from: A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila
- 负责人：
- DOI：
- doi:10.5061/dryad.8f0r6j9
- 摘要：
- s of natural variants in this pathway remain poorly understood. Here we investigate how two clinal alternative alleles at foxo, a transcriptional effector of IIS
Data from: Tang-Nai-Kang alleviates pre-diabetes and metabolic disorders by inducing a gene expression switch toward fatty acid oxidation in SHR.Cg
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- 关键词：
- DOI：
- doi:10.5061/dryad.3hj96
- 摘要：
- ?) and forkhead transcription factor 1 (FOXO1), and induced the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in different tissues. These
Data from: Developmental exposure to PCB153 (2,2’,4,4’,5,5’-hexachlorobiphenyl) alters circadian rhythms and the expression of clock and metabolic genes
- 负责人：
- DOI：
- doi:10.5061/dryad.p1b140p
- 摘要：
- were common to all treatment groups. KEGG pathway analysis revealed enrichment of genes related to circadian rhythm, FoxO signaling
Supporting data for "Evidence of Evolutionary History and Selective Sweeps in the Genome of Meishan Pig Reveals Its Genetic and Phenotypic Characteristics"
- 负责人：
- DOI：
- doi:10.5524/100429
- 摘要：
- protein-coding genes have undergone positive selection. Notably, the FoxO signaling pathway with significant enrichment signal and the harbored gene IGF1R were li
Data from: Insulin signaling’s role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.35g4j2q
- 摘要：
- , InR2) and Foxo, a growth inhibitor. We then performed morphometric measurements on horns, a highly nutrition-sensitive trait, and genitalia, a lar
