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Data from: Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle
- 负责人：
- DOI：
- doi:10.5061/dryad.s3443
- 摘要：
- a novel method called rapid quantitative pharmacodynamic imaging. This method combines pharmacokinetic-pharmacodynamic modeling, repeated small doses
\u2022\tRegulatory requirement for drug development and approval in United States: review
- 负责人：
- 关键词：
- 111701 Aboriginal and Torres Strait Islander Health 111001 Aged Care Nursing 111702 Aged Health Care 110301 Anaesthesiology 110901 Autonomic Nervous System 111501 Basic Pharmacology Biomarkers 110601 Biomechanics 111201 Cancer Cell Biology 111202 Cancer Diagnosis
- DOI：
- doi:10.6084/m9.figshare.3381274.v1
- 摘要：
- involving drugdiscovery, laboratory development, animal studies, clinicaltrials, and regulatory registration. This lengthy process isnecessary to assure
Data from: Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and r
- 负责人：
- Lammens, Lieve
- DOI：
- doi:10.5061/dryad.5vv774m
- 摘要：
- d dispersion (ASD) formulation was developed. As this formulation results in improved systemic absorption, the pharmacokinetic and toxicological profile
Data from: Overview of phase IV clinical trials for postmarket drug safety surveillance: a status report from the ClinicalTrials.gov registry
- 负责人：
- DOI：
- doi:10.5061/dryad.3t6sc
- 摘要：
- s of contemporary phase IV clinical trials and whether these studies are of sufficient quality to advance medical knowledge in pharmacovigilance. We aimed
Data from: Hepatotoxicity of isotretinoin in patients with acne and Gilbert's syndrome: comparative study
- 负责人：
- DOI：
- doi:10.5061/dryad.nr4k8
- 摘要：
- treated with isotretinoin because of severe acne. Setting: Dermatology outpatient clinics of three regional hospitals of Jaén (Spain). Participants: Over 4?year
Data from: Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.44j0zpc9v
- 摘要：
- b preclinical pharmacology data support its therapeutic potential in CDK9- or CDK2-dependent cancers and as a rational combination with BCL2 inhibitors
Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis
- 负责人：
- DOI：
- doi:10.5061/dryad.4hk2039
- 摘要：
- Myasthenia Gravis Quality of Life scale), pharmacokinetics, pharmacodynamics, and immunogenicity. Results: Of the 35 screened patients, 24 were enrolled and r
Data from: Postmarket safety in Canada: are significant therapeutic advances and biologics less safe than other drugs? A cohort study
- 负责人：
- DOI：
- doi:10.5061/dryad.fg679
- 摘要：
- e the probability of acquiring a postmarket safety warning in Canada in four different groups of drugs: (1) traditional medications versus biologics; (2) medica
Data from: How do doctors and nurses manage delirium in intensive care units? A qualitative study using focus groups.
- 负责人：
- DOI：
- doi:10.5061/dryad.5rq76
- 摘要：
- e identified: (1) the professional perspective on delirium; (2) implementing pharmacological and non-pharmacological treatment for deli
Data from: Perceptions of research bronchoscopy in Malawian adults with pulmonary tuberculosis: a cross-sectional study.
- 负责人：
- DOI：
- doi:10.5061/dryad.sp152
- 摘要：
- Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological
