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Data from: Independent acquisition of sodium selectivity in bacterial and animal sodium channels
负责人:
关键词:
Bacterial sodium channels Ancestral state reconstruction Phylogeny
DOI:
doi:10.5061/dryad.t8f5m
摘要:
the channel — its method of ‘gating’. The voltage-gated sodium (Nav) and calcium channels (Cav), which drive the upstroke of action potentials and transduce
Data from: Calcium dynamics regulating the timing of decision-making in C. elegans
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DOI:
doi:10.5061/dryad.h3680
摘要:
sion by a gradual increase in intracellular calcium concentration ([Ca2+]i), which occurs via L-type voltage-gated calcium channels in a pair of olfactory ne
Data from: Na+ influx via Orai1 inhibits intracellular ATP induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation
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关键词:
DOI:
doi:10.5061/dryad.202fn
摘要:
a calcium channels remain unknown. ?-SNAP is a crucial component of Orai1 channels, and its depletion disrupts the functional assembly of Orai1 multimers. Here we sh
Data from: Mutations of the calcium channel gene cacophony suppress seizures in Drosophila
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关键词:
epilepsy;calcium channel;seizure-suppression;sodium channel;cacophony
DOI:
doi:10.5061/dryad.nc763
摘要:
such as epilepsy. The BS mutant parabss1, caused by a gain-of-function mutation of the voltage-gated Na+ channel gene, is extremely seizure-sensitive
Data from: Cellular hypertrophy and increased susceptibility to spontaneous calcium-release of rat left atrial myocytes due to elevated afterload
负责人:
关键词:
spontaneous calcium release;atrial myocytes;hypertrophy;pressure overload remodelling;calcium transients
DOI:
doi:10.5061/dryad.70gk2
摘要:
center were much smaller. Western blotting showed a decreased L-type Ca channel expression but no significant changes in RyR or RyR phosphorylation
Data from: EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling
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关键词:
DOI:
doi:10.5061/dryad.bb46h5s
摘要:
izes at the synapse, where it further modulates dopamine signaling in cooperation with the orthologue of an R-type voltage-gated calcium channel. Our findings unveil
Data from: Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
负责人:
关键词:
Heart failure;calcium;calcium;cardiac fibrosis;store-operated Ca2+ entry
DOI:
doi:10.5061/dryad.74f47
摘要:
17±1.1%); however, Ca2+ influx via store-operated Ca2+ entry [SOCE /CRAC (Ca2+ release-activated)] channels was significantly (P?0.05) greater in HF
Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC
负责人:
关键词:
excitation-contracting coupling;human pluripotent stem cell derived cardiomyocytes;drug testing;drug screening;human pluripotent stem cells
DOI:
doi:10.5061/dryad.67c92vm
摘要:
on ion channels but they do not always accurately predict contractile responses of the human heart. This is in part attributable to their immaturity
Transient receptor potential A1 channel in nociceptive sensation of weak acids and carbon dioxide and its regulation
负责人:
关键词:
calcium Neuroscience TRPA1 trigeminal neurons nociception weak acids carbon dioxide
DOI:
doi:10.25549/usctheses-m3695
摘要:
is the transient receptor potential A1 (TRPA1) channel, which is the principle detector for a variety of environmental irritants and pungent compounds, such as mustard oil
Data from: The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex
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关键词:
DOI:
doi:10.5061/dryad.1976kg3
摘要:
The mitochondrial calcium uniporter is a Ca2+ channel that regulates intracellular Ca2+ signaling, oxidative phosphorylation, and apoptosis. It conta

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