Data from: High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

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Bioactive molecules;Yeast;Chemogenomic profiling;Target identification;genomics;hop;Mechanism of action;Saccharomyces cerevisiae;Hip

DOI：

doi:10.5061/dryad.v5m8v

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to small molecules. Using an optimized platform, we provide the relative sensitivities of the heterozygous and homozygous deletion collections for nearly 1800

Development of targeted therapies for peroxisome biogenesis disorders

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Molecular Biology peroxisome biogenesis disorders peroxins PEX1 high-content screening small molecules induced pluripotent stem cells HepG2 cells Pex1-p.G844D mouse

DOI：

doi:10.25549/usctheses-c40-298640

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available. ? In this dissertation, I described the identification and characterization of small molecules that enhance peroxisome assembly and functi

Genetic and chemical characterization of two highly-reducing polyketide synthase clusters from Aspergillus species

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Pharmaceutical Sciences natural products biosynthesis Aspergillus citreoviridin aspernidgulenes

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doi:10.25549/usctheses-c40-499283

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l secondary metabolites. The first goal is important because understanding the biosynthesis of complex organic molecules can inspire biomimetic synthesis strategies. Furt

Data from: Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides

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DOI：

doi:10.5061/dryad.gh7h8

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Background: Various bacteria can use non-ribosomal peptide synthesis (NRPS) to produce peptides or other small molecules. Conserved features

Data from: Random sequences are an abundant source of bioactive RNAs or peptides

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random sequences;growth advantage;E. coli;de novo evolution

DOI：

doi:10.5061/dryad.6f356

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t random sequences may become an effective new source of molecules for studying cellular functions, as well as for pharmacological activity screening.

Data from: Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

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Morphogen;hedgehog;patterning;wing;drosophila melanogaster

DOI：

doi:10.5061/dryad.6b058n7

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on. Hence, palmitoylated membrane anchors restrict morphogen spread until site-specific processing switches membrane-bound Hh into bioactive forms