SKN-1 coordination of stress adaptation, metabolism, and resource allocation in Caenorhabditis elegans

负责人：

关键词：

Asdf Molecular Biology SKN-1 Nrf2 metabolism stress response resource allocation lipids high carbohydrate diet ALH-6

DOI：

doi:10.25549/usctheses-c40-260305

摘要：

Animals must continually assess nutrient availability to develop appropriate strategies for survival and reproductive success. It is no secret that nutritional state plays a large role in both aging and health. Appropriate cellular energy usage is not only crucial for animal starvation survival, but is also important for diseases such as obesity and cancer, which characteristically have metabolic dysfunction. C. elegans are exceptionally well poised to handle bouts of starvation as resource availability in the wild varies greatly. We recently discovered an evolutionarily conserved pathway, regulated by the cytoprotective transcription factor SKN-1/Nrf2, which integrates diet composition and availability with utilization for survival. These responses have potent impact on organismal physiology and remarkably are influenced by current and parental life history events, including choice of diet. It is important to be cognizant of dietary intake and the impact that this can have throughout the life-history of the nematode, Caenorhabditis elegans.