Data from: Deep sequencing of a candidate region harboring the SOX9 gene for the canine XX disorder of sex development

负责人：

Grzemski, Adrian

关键词：

SOX9 dog intersexuality DSD MAGI2 CNV lincRNA RevSex

DOI：

doi:10.5061/dryad.65th7

摘要：

harboring the SOX9 gene. We applied a genome-wide association study and targeted next-generation sequencing techniques to compare DSD and normal female

Data from: Effect of craniofacial genotype on the relationship between morphology and feeding performance in cichlid fishes

负责人：

Albertson, Craig

关键词：

sox9 Functional morphology Evolutionary genetics Adaptive radiation Suction feeding

DOI：

doi:10.5061/dryad.mf287

摘要：

ecially robust in animals with the specialist allele at sox9b, a well-characterized regulator of craniofacial development. These data suggest a novel role

Data from: Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas

负责人：

关键词：

lineage;differentiation;fate;3-D live imaging;cell cycle;cell division;Embryo;HNF1B;Tracking;explant;progenitors;systems dynamics;pancreas;clonal analysis;Mathematical model;SOX9;stochastic cell fate;diabetes;endocrine;NEUROG3

DOI：

doi:10.5061/dryad.4b58d

摘要：

Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine, ductal, and acinar cells but become bipotent by embryonic day 13.5, giving rise to endocrine cells and ductal cells. However, the dynamics of individual progenitors balancing self-renewal and lineage-specific differentiation has never been described. Using three-dimensional live imaging and in vivo clonal analysis, we reveal the contribution of individual cells to the global behaviour and demonstrate three modes of progenitor divisions: symmetric renewing, symmetric endocrinogenic, and asymmetric generating a progenitor and an endocrine progenitor. Quantitative analysis shows that the endocrine differentiation process is consistent with a simple model of cell cycle–dependent stochastic priming of progenitors to endocrine fate. The findings provide insights to define control parameters to optimize the generation of ?-cells in vitro.

Data from: Identification, visualization and clonal analysis of intestinal stem cells in fish

负责人：

关键词：

DOI：

doi:10.5061/dryad.591gf

摘要：

intestinal crypts and stem cells in this compartment are characterized by the expression of sox9, axin2 as well as lgr5, homologs of mammalian ISC markers