Data from: Establishment of a refined oral glucose tolerance test in pigs, and assessment of insulin, glucagon and glucagon-like peptide-1 responses

负责人：

关键词：

ivgtt pig ogtt glucose insulin glucagon-like peptide-1

DOI：

doi:10.5061/dryad.n3f4j

摘要：

, as well as describing intravenous glucose tolerance test (IVGTT) in the same age group. The refined porcine OGTT will reflect that used in children and adolescents

Population pharmacokinetic\/pharmacodynamic modeling: evaluation of maximum likelihood expectation maximization method in ADAPT 5

负责人：

关键词：

IVGTT Biomedical Engineering population PK\/PD maximum likelihood expectation maximization minimal model ADAPT

DOI：

doi:10.25549/usctheses-m143

摘要：

Unrestricted Maximum likelihood estimation via the expectation maximization algorithm (EML) was implemented into ADAPT 5 to support population pharmacokinetic / pharmacodynamic studies. Two detailed simulation studies were conducted using a one compartment pharmacokinetic model with sparse data and a complex pharmacokinetic / pharmacodynamic model to evaluate this algorithm. Additionally, a population analysis of the minimal model for the intravenous glucose tolerance test in mice was performed as an example of biological study using real data. In the simple pharmacokinetic model, less than 1% mean prediction errors were obtained for the estimated population mean and covariance parameters. For the complex model, the EML estimation resulted in prediction error less than 8% for the mean parameters and these results were not influenced by different initial guesses for model parameters. The EML estimation for the animal study resulted in a correlation coefficient between predicted and measured values of glucose concentration in plasma of 0.97.