Development of targeted therapies for peroxisome biogenesis disorders

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关键词：

HepG2 cells Molecular Biology peroxisome biogenesis disorders peroxins PEX1 high-content screening small molecules induced pluripotent stem cells Pex1-p.G844D mouse

DOI：

doi:10.25549/usctheses-c40-298640

摘要：

the development of new model systems of PBDs, including induced pluripotent stem cells (iPSCs), HepG2 cells and mice. We generated iPSCs from primary skin fibroblasts

in HepG2 cells

负责人：

关键词：

DILI;Flutamide;2-hydroxyflutamide;Mitochondria

DOI：

doi:10.5061/dryad.jj456

摘要：

. In this study we have used the acute glucose or galactose-conditioning of HepG2 cells to compare the mitochondrial toxicity of flutamide, 2-hydroxyflutamide

Data from: Synthesis of gypsogenin derivatives with capabilities to arrest cell cycle and induce apoptosis in human cancer cells

负责人：

关键词：

Gypsogenin derivatives;Cell cycle arrest;Cytotoxic activity;apoptosis

DOI：

doi:10.5061/dryad.35j3j

摘要：

lines (A549, LOVO, SKOV3 and HepG2). Low IC50 values were obtained especially for the carboxamides 7a–7j, for an oxime derivative 3 and a (2,4-d