A crystal of a compound represented by the generalformula (I) or a pharmacologically acceptable saltthereof has an excellent LCAT-activating effect and isuseful as an active ingredient in a therapeutic orprophylactic agent for arteriosclerosis, arterioscleroticheart disease, coronary heart disease (including heartfailure, myocardial infarction, angina pectoris, cardiacischemia, cardiovascular disturbance, and restenosiscaused by angiogenesis), cerebrovascular disease(including stroke and cerebral infarction), peripheralvascular disease (including diabetic vascularcomplications), dyslipidemia, hypo-HDL-cholesterolemia,or renal disease, particularly, an anti-arterioscleroticagent, wherein R1 is a hydrogen atom or a hydroxy group,and R is a 2-(trifluoromethyl)pyrimidin-5-yl group or a5-(trifluoromethyl)pyrazin-2-yl group.
