This invention provides a physiological monitoring system combined with a mobile device, which is capable of transmitting signals between a sensing device and the mobile device through an audio interface by modulation and demodulation of audio signals by encoding and decoding of digital signals, so that it can be widely used in mobile devices with an audio jack, and has wide applicability and is more convenient to use. Moreover, since the mobile device itself has the functions of computing and processing, transmission and storage, interface operation, displaying the results, network connection, capturing images, power supply and other functions, the element requirement of the sensing device can be significantly simplified, and the volume and the manufacturing costs can be reduced.本發明係提供一種結合行動裝置之生理監測系統,可透過音訊介面於感測裝置及行動裝置間以調變、解調變之音源訊號方式或編碼、解碼之數碼訊號等方式傳輸訊號,故可廣泛地應用於具有音訊接孔之行動裝置,適用性廣、使用上更為便利,且因行動裝置本身即具備運算處理、傳輸儲存、介面操作、顯示結果、網路連線、擷取影像、電力供應等功能,使感測裝置之元件需求大幅簡化,可減少其外觀體積與製造成本。