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AGOMELATINE HYDROBROMIDE HYDRATE AND PREPARATION THEREOF
专利权人:
LES LABORATOIRES SERVIER
发明人:
SHAN, Hanbin,YUAN, Zhedong,ZHU, Xueyan,ZHANG, Peng,PAN, Hongjuan,YU, Xiong
申请号:
TN2012000436
公开号:
TN2012000436A1
申请日:
2012.08.31
申请国别(地区):
TN
年份:
2014
代理人:
摘要:
An agomelatine hydrobromide hydrate of formula (I), in which X is Br, preparation method and use thereof as well as pharmaceutical composition containing it are provided. The solubility of the agomelatine hydrobromide hydrate obtained by the present method is significantly higher than that of agomelatine. Therefore, it is more suitable for manufacturing pharmaceutical formulations. In addition, the product has higher stability and purity. The present product of high purity can be obtained through a simple process, rather than process with complicated steps.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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