The present invention provides for prevention and/or treatment of neurologicalor neuropsychiatric disorders involvingabnormal D1-D2 dopamine receptor coupling and/or activation. Methods andagents are provided for modulatingdopamine receptor function arising from D1-D2 coupling and/or activation.Agents of the present invention include fragments ofD2 receptor or D1 receptor that can disrupt D1-D2 coupling.