Method and device for determining the elastic modulus of a region of interest in biologic tissue. In a first step of the method, a sequence of elasticity images (2) and a sequence of B-mode ultrasound images (1) of the region of interest are acquired simultaneously. Then, at least one sub-sequence of the B-mode ultrasound images (4；8) of the region of interest representing a resting state of the region of interest from said sequence of B-mode ultrasound images (1) is generated. Based on said sub-sequence of the B-mode ultrasound images (4；8), a subsequence of the elasticity images (6；12) is generated by selecting and/or modifying those elasticity images (2). Finally, the elastic modulus of the region of interest is determined based on the sub-sequence of the elasticity images (6；12). Further, the present invention relates to a method for determining changes of the elastic modulus of a tissue, a method of identification of biological tissue based on the determined elastic modulus as well as a device for determining the elastic modulus of a biological tissue.
