Arthur E. Warrington;Larry R. Pease;Moses Rodriguez
发明人:
Moses Rodriguez,Arthur E. Warrington,Larry R. Pease
申请号：
US13880415
公开号：
US20130280167A1
申请日:
2011.10.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Specific binding members, particularly human antibodies, particularly recombinant antibodies, and fragments thereof, which are capable of binding to and recognizing neurons in the CNS and eliciting responses in CNS neurons are provided. The antibodies are useful for neuroprotection and in the diagnosis and treatment of conditions associated with nerve damage, injury or degeneration and neurodegenerative disease. The antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or neuroactive agents and/or with other antibodies or fragments thereof. Antibodies are exemplified by the antibodies IgM12 and IgM42 whose sequences are provided herein.
