Novel compounds isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonistand pharmaceutical compositions containing the same
The present invention relates to a novel compound as Vanilloid Receptor 1 (VR1； TRPV1) antagonist, an isomer thereof or a pharmaceutically acceptable salt thereof； And a pharmaceutical composition containing the same. The present invention relates to a pharmaceutical composition for treating pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, Irritable bowel syndrome, fecal urgency, respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer ulcer, inflammatory diseases, ear disease, heart disease, and the like.본 발명은 바닐로이드 수용체(Vanilloid Receptor 1； VR1； TRPV1) 길항제로서의 신규 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염； 및 이를 포함하는 약학 조성물에 관한 것이다.본 발명은 통증(pain), 편두통(migraine), 관절통(arthralgia), 신경통(neuralgia), 신경장애(neuropathies), 신경손상(nerve injury), 피부 이상(skin disorder), 방광 과민증(urinary bladder hypersensitiveness), 과민성대장 증후군(irritable bowel syndrome), 급성 배변(fecal urgency), 호흡이상(respiratory disorder), 피부, 눈 또는 점막의 자극(irritation of skin, eye or mucous membrane), 위-십이지장 궤양(stomach-duodenal ulcer), 염증성 질환(inflammatory diseases), 귓병(ear disease), 심장질환(heart disease) 등의 질환들을 예방 또는 치료하는 약학 조성물을 제공한다.
