JAC INHIBITING TRIAZOLPYRIDINE COMPOUNDS AND METHODS

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专利权人:

ДЖЕНЕНТЕК; ИНК. (US)

发明人:

ЧЖУ Бин-Янь (US),СИУ Майкл (US),МАГНУСОН Стивен Р. (US),ПАСТОР Ричард (CN),ХАЙИН Хэ (CN),ИСУН Сяо (CN),ЦЗИФУ Чжэн (CN),СИН Сюй (CN),ЦЗЮНЬПИН Чжао (CN),ХАРЛИ Кристофер А. (GB),ЛЯН Цзюнь (US),ЛЮ Венди (

申请号：

RU2011101898/04

公开号：

RU2011101898A

申请日:

2009.06.19

申请国别(地区):

RU

年份:

2012

代理人:

摘要：

1. The compound of formula I! ! its enantiomers, diastereomers, tautomers or pharmaceutically acceptable salts, where! R1 is H, C (O) ORa, phenyl, C1-C9 heterocyclyl or C1-C9 heteroaryl, wherein said phenyl and heteroaryl are optionally substituted with 1-5 R6； ! R2 is phenyl, C1-C9 heteroaryl or C1-C9 heterocyclyl, where phenyl, heteroaryl and heterocyclyl are optionally substituted with 1-5 R7； ! R3, R4 and R5 independently represent H, CH3, CH2CH3, OCH3, CF3, F or Cl； ! R6 independently is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C0-C6 alkyl) ORa, (C0-C6 alkyl) NRaRb, halogen, CN, CF3, S (0) 1-2NRaRb , C (O) Ra, NRaC (0) ORb, NRaS (O) 1-2NRb, (C0-C6 alkyl) C1-C5 heteroaryl, (C0-C6 alkyl) C1-C5 heterocyclyl, (C0-C6 alkyl) C3 -C6 cycloalkyl, (C0-C6 alkyl) C6-C9 aryl, (C0-C6 alkyl) C (O) ORa, C (O) (C0-C5 alkyl) NRaRb, C (O) (C0-C5 alkyl) ( C1-C5 heterocyclyl), C (O) NRa (C0-C5 alkyl) (C1-C5 heterocyclyl), C (O) NRa (C0-C5 alkyl) (C3-C6 cycloalkyl), C (O) NRa (C0- C5 alkyl) (C1-C5 heteroaryl), C (O) NRa (C1-C5 alkyl) NRaRb or C (O) NRa (C1-C5 alkyl) (C6 aryl), wherein said alkyl, alkenyl and alkynyl are optionally substituted with 1- 5 substituents independently selected from ORa, NRcRd, oxo halogen, and said aryl, heterocyclyl, heteroaryl and cycloalkyl are optionally substituted with 1-5 substituents independently selected from ORa, oxo, halogen, CF3, NRcRd, C1-C4 alkyl, (C0-C6 alkyl) C1-C5 heterocyclyl and C (O ) (C1-C4 alkyl)； ! R7 independently is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C0-C6 alkyl) ORa, (C0-C6 alkyl) NRaRb, (C0-C6 alkyl) (C6-C9 aryl), halogen, C (O) NRaRb, NRaC (O) Rb, SO2 (C1-C6 alkyl), SO2NRaRb, CN, CF3, CH2CF3, nitro, S (O) (C1-C6 alkyl), S (0) NRaRb, NRaS (O) 1-2Rb, C (O) Ra, C (O) ORa, (C0-C6 alkyl) C1-C5 heteroaryl, (C0-C6 alkyl) C1-C5 heterocyclyl or (C0-C6 alkyl) C3-C6 cycloalkyl, wherein said alkyl, alkenyl and alkynyl are optionally substituted with 1-5 substituents independently selected from oxo, NRaRb, ORa, and haloge

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