This invention provides quinazoline compounds of the formula: wherein: R1 is halo； R2 is H or halo； R3 is a) C1-C3 alkyl, optionally substituted by halo； or b) &mdash；(CH2)n-morpholino, &mdash；(CH2)n-piperidine, &mdash；(CH2)n-piperazine, &mdash；(CH2)n&mdash；-piperazine-N(C1-C3 alkyl), &mdash；(CH2)n-pyrrolidine, or &mdash；(CH2)n-imidazole； n is 1 to 4； R4 is &mdash；(CH2)m-Het； Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2； m is 1-3； and X is O, S or NH； or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
