University of Cincinnati;U.S. Department of Veterans Affairs;Children's Hospital Medical Center
发明人:
Fred D. Finkelman,Marat V. Khodoun,Suzanne C. Morris
申请号：
US15836095
公开号：
US20180092929A1
申请日:
2017.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of treating a subject suffering from an allergic disorder is provided, the method including inducing rapid desensitization to an allergen, the rapid desensitization effectuated by: administering to the subject a plurality of equal doses of a first anti-FcεRIα monoclonal antibody, wherein the plurality of equal doses are administered over a 6 to 8 hour period and wherein each dose is lower than a level required to induce shock, thereby inducing rapid desensitization to the allergen. Monoclonal antibodies and methods of co-administering or consecutively administering a combination thereof to effectuate rapid desensitization are also provided.
