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二氫咪唑並噁唑衍生物
专利权人:
LTD.;TAISHO PHARMACEUTICAL CO.
发明人:
URABE, HIROKI,浦部洋树,浦部洋樹,SHIMONO, RIE,下野梨絵,TAMITA, TOMOKO,民田智子,HATTORI, NOBUTAKA,服部信隆,SAKAGAMI, KAZUNARI,坂上一成,MATSUDA, YOHEI,松田洋平,YASUHARA, AKITO,安原明登,MASUDA, SEIJI,增田诚治,增
申请号:
TW101139720
公开号:
TW201333015A
申请日:
2012.10.26
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
The present invention relates to: a dihydroimidazooxazole derivative represented by general formula (IA) or a pharmaceutically acceptable salt thereof, which has positive allosteric modulator activity on metabotropic glutamate receptor subtype 2 (mGlu2 receptor); and a pharmaceutical product for prevention or treatment of a disease selected from the group consisting of schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders, depression, attention deficit/hyperactivity disorder (AD/HD), drug dependence, convulsions, tremor and sleep disorders, said pharmaceutical product containing the dihydroimidazooxazole derivative or a pharmaceutically acceptable salt thereof as an active ingredient.本發明係關於對於代謝型谷胺酸受體亞型2(mGlu2受體)具有正變構調節劑(Positive allosteric modulators)作用之一般式(IA)所示新穎之二氫咪唑並噁唑衍生物、或其醫藥上可被許可的鹽。其可作為精神分裂症、阿茲海默症病、認知功能障礙、痴呆、焦慮障礙、鬱悶病、AD/HD(缺乏關注/多動性障礙)、藥物依存、痙攣、發抖、睡眠障礙等疾病的預防或治療用醫藥時為有用。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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