Δ8 desaturases and their use in making polyunsaturated fatty acids

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专利权人:

Howard Glenn Damude;Quinn Qun Zhu

发明人:

Howard Glenn Damude,Quinn Qun Zhu

申请号：

US12825537

公开号：

US08318463B2

申请日:

2010.06.29

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA； 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA； 20:3 ω-6) and/or eicosatrienoic acid (ETrA； 20:3 ω-3) to eicosatetraenoic acid (ETA； (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.

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