The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to CDH17 with high affinity. Nucleic acid molecules encoding CDH17 antibodies, expression vectors, host cells and methods for expressing CDH17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CDH17 antibodies are also provided. Methods for detecting CD-H17, as well as methods for treating carious cancers, including gastric cancer, pancreatic cancer, colon cancer and colorectal cancer, are disclosed.本開示は、高い親和性でCDH17へ特異的に結合する単離されたモノクローナル抗体を含む、抗体を提供する。また、CDH17抗体をコードする核酸分子、発現ベクター、宿主細胞及びCDH17抗体を発現する方法も提供される。さらに、CDH17抗体を含む二重特異性分子及び医薬組成物も提供される。CDH17を検出する方法に加え、胃癌、膵臓癌、結腸癌、及び結腸直腸癌を含む種々の癌を治療する方法も開示される。【選択図】図１
