CROOKE, HELEN RACHEL,SHEA, JACQUELINE ELIZABETH,FELDMAN, ROBERT GRAHAM,GOUTEBROZE, SYLVAIN GABRIEL,LE GROS, FRANCOIS-XAVIER
申请号：
CA2481186
公开号：
CA2481186C
申请日:
2003.04.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Disclosed and claimed are a mutant of a gram negative bacterium, wherein saidbacterium has at least one mutation in a nucleotide sequence which codes for apolypeptide having an identity which is equal or more than 70 %, 75 % , 80 %,85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence codedby a nucleotide sequence selected from the group consisting of nucleotidesequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37,40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93 saidmutation resulting in attenuated virulence of the bacterium. Immunogeniccompositions and vaccines containing such as a mutant are also disclosed andclaimed.
