SINGH, SHARAT,HOE, NICHOLAS,LOCKTON, STEVE,HAUENSTEIN, SCOTT,OHRMUND, LINDA
申请号：
CA2839792
公开号：
CA2839792A1
申请日:
2012.05.10
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNFa inhibitor for the treatment of a TNFa-mediated disease or disorder.
