The method that the grain Trail Tong Time Victoria of the small activity Drug object ingredient (API) of Yi Seed Minus holds its polymorphic forms, the method includes Tong Over Xia raised Pressure power, and Kong Erosion Come processes the activity Drug object ingredient Bu Sudden. The method Gifted Election includes the step Sudden of point active constituent of the processing of From powder type, wherein described, to divide From step Sudden packet to include Over Filter or Spray the Mist universe dry. This Hair of Tong Over bright Fang Fa System Prepare Teeth usually has low what 2.5 span value.一種減小活性藥物成分(API)的粒徑同時維持其多晶型形式的方法，所述方法包括通過在升高的壓力下空蝕來加工所述活性藥物成分的步驟。所述方法優選包括分離粉末形式的加工的活性成分的步驟，其中所述分離步驟包括過濾或噴霧乾燥。通過本發明的方法製備的顆粒通常具有低於2.5的跨度值。
