P97-IDS fusion proteins

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专利权人:

Inc.;biOasis Technologies

发明人:

Vitalis, Timothy Z.,Gabathuler, Reinhard

申请号：

AU2015219339

公开号：

AU2015219339A1

申请日:

2015.02.12

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Provided are fusion proteins between p97 (melanotransferrin) and iduronate-2-sulfatase (IDS), and related compositions and methods of use thereof, for instance, to facilitate delivery of IDS across the blood-brain barrier (BBB) and/or improve its tissue penetration in CNS and/or peripheral tissues, and thereby treat and/or diagnose Hunter Syndrome (Mucopolysaccharidosis type II； MPS II) and related lysosomal storage disorders, including those having a central nervous system (CNS) component.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/