COMPOSITION FOR ALLEVIATING ATOPY DERMATITIS USING EXTRACT OF CAREYA ARBOREA农业专利-农业学术服务平台

专利权人:: 대한민국(환경부 국립생물자원관장);NATIONAL INSTITUTE OF BIOLOGICAL RESOURCES;재단법인 경기도경제과학진흥원;GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR

发明人:: KANG, JAE SHINKR,강재신,LEE, JAE HOKR,이재호,YOO, EUN HWAKR,유은화,KRY MASPHALKH,크라이 마스팔,CHHENG KIMSUNKH,챙 킴선,JUNG, YOUNG HOONKR,정영훈,AHN, EUN KYUNGKR,안은경,LEE, JAE YEONKR,이재연,KANG, JAE SHIN,LEE, JAE HO,YOO, EUN HWA,KRY MASPHAL,CHHENG KIMSUN,JUNG, YOUNG HOON,AHN, EUN KYUNG,LEE, JAE YEON

摘要：: Disclosed is a composition effective in atopy dermatitis using an extract of Careya arborea, which inhibits the expression of MDC and TARC in HaCaT cells, human keratinocyte cell line treated with INF-y and TNF-a, lowers a SCORAD index in an animal model in which atopic dermatitis was induced by dinitrochlorobenzene (DNCB), and lowers the serum IgE concentration.COPYRIGHT KIPO 2018본 발명은 INF-γ와 TNF-α로 처리된 인간각질형성세포주인 HaCaT 세포에서 MDC 및 TARC의 발현을 억제하고, DNCB(dintrochlorobenzene)로 아토피 피부염이 유발된 동물모델에서 아토피 중증도 지수(SCORAD index)를 낮추고 혈중 IgE의 농도를 낮추는 등 아토피 피부염에 유효한 카레야 아르보레아 추출물을 개시한다.