A method and apparatus for selecting an electrode combination in a cardiac pacing device. In some instances, this may include: implanting a plurality of cardiac electrodes supported by one or more leads in a patient; receiving user-determined electrode combination selection criteria from a user; evaluating, for each electrode combination of a plurality of electrode combinations of a plurality of cardiac electrodes, which electrode combination best satisfies the user-determined electrode combination selection criteria; selecting the electrode combination that best satisfies the user-determined electrode combination selection criteria; and programming an implantable pacing circuit to deliver a cardiac pacing therapy to the patient's heart that uses the selected electrode combination.