Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of c-Met transcript (mRNA transcript), thereby inhibiting expression of c-Met without inducing immune responses, and use of the siRNA for prevention and/or treatment of cancer. The siRNA that complementarily binds to c-Met-encoding mRNA may inhibit expression of c-Met, which is commonly overexpressed in almost all cancer cells, through RNA interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.
