n- [3-fluoro-4 - ({6- (methyloxy) -7 - [(3-morpholin-4-ylpropyl) oxy] -quinolin-4-yl} oxy) phenyl] -n '- () 4-Fluorphenyl) cyclopropane-1,1-dicarboxamide, pharmaceutical composition with them, methods of preparing them and treating cancer

• 收藏
• 分享

专利权人:

EXELIXIS; INC.

发明人:

CANNON, HILARY,IGO, DAVID,TRAN, TRI

申请号：

BR112012001118

公开号：

BR112012001118A2

申请日:

2010.07.16

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

This invention relates to three crystalline forms of N-[3-fluoro-4-((6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yloxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. Compound (I), designated as Form A, Form B, and Form C. The invention provides methods for treatment of cancer by exploiting the modulation of protein kinase activity. The invention also provides pharmaceutical compositions containing a crystalline form of Compound (I) and a pharmaceutically acceptable excipient.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/